BMJ:鸡蛋摄入与心血管疾病风险无关
  • 纳入173 563名女性,42 055名男性,最长随访32年,进行前瞻性分析;同时额外纳入27项研究(共计1 720 108名参与者),进行荟萃分析;
  • 基于队列的前瞻性分析显示,与每月摄入<1个鸡蛋相比,每天摄入≥1个鸡蛋并未与心血管疾病风险相关;
  • 更新后的荟萃分析显示,每天每增加摄入1个鸡蛋与心血管疾病、冠心病和中风风险并不相关;
  • 基于地域的亚组分析显示,美国和欧洲人群中鸡蛋摄入与心血管疾病风险无关,但在亚洲队列中发现了负相关性。
主编推荐语
flying dutchman
BMJ近期发表的一项前瞻性队列合并荟萃分析研究显示,鸡蛋摄入(每天摄入≥1个鸡蛋与每月摄入<1个鸡蛋相比)与心血管疾病风险无关。亚组分析甚至显示,亚洲人群中,鸡蛋摄入与心血管疾病风险呈负相关。本研究结论又与去年发表在JAMA上的研究相反(查看文章)。研究设计间的差异(收集了哪一时期的鸡蛋摄入信息),以及对结局定义的不同(是否考虑心力衰竭),或许导致了研究结果的差异。
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Egg consumption and risk of cardiovascular disease: three large prospective US cohort studies, systematic review, and updated meta-analysis

鸡蛋摄入量与心血管疾病风险:三项大型前瞻性美国队列研究,及系统回顾和最新荟萃分析

10.1136/bmj.m513

2020-03-04, Article

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Abstract:收起
Objective : To evaluate the association between egg intake and cardiovascular disease risk among women and men in the United States, and to conduct a meta-analysis of prospective cohort studies.
Design : Prospective cohort study, and a systematic review and meta-analysis of prospective cohort studies.
Setting : Nurses’ Health Study (NHS, 1980-2012), NHS II (1991-2013), Health Professionals’ Follow-Up Study (HPFS, 1986-2012).
Participants : Cohort analyses included 83 349 women from NHS, 90 214 women from NHS II, and 42 055 men from HPFS who were free of cardiovascular disease, type 2 diabetes, and cancer at baseline.
Main outcome measures: Incident cardiovascular disease, which included non-fatal myocardial infarction, fatal coronary heart disease, and stroke.
Results : Over up to 32 years of follow-up (>5.54 million person years), 14 806 participants with incident cardiovascular disease were identified in the three cohorts. Participants with a higher egg intake had a higher body mass index, were less likely to be treated with statins, and consumed more red meats. Most people consumed between one and less than five eggs per week. In the pooled multivariable analysis, consumption of at least one egg per day was not associated with incident cardiovascular disease risk after adjustment for updated lifestyle and dietary factors associated with egg intake (hazard ratio for at least one egg per day v less than one egg per month 0.93, 95% confidence interval 0.82 to 1.05). In the updated meta-analysis of prospective cohort studies (33 risk estimates, 1 720 108 participants, 139 195 cardiovascular disease events), an increase of one egg per day was not associated with cardiovascular disease risk (pooled relative risk 0.98, 95% confidence interval 0.93 to 1.03, I2=62.3%). Results were similar for coronary heart disease (21 risk estimates, 1 411 261 participants, 59 713 coronary heart disease events; 0.96, 0.91 to 1.03, I2=38.2%), and stroke (22 risk estimates, 1 059 315 participants, 53 617 stroke events; 0.99, 0.91 to 1.07, I2=71.5%). In analyses stratified by geographical location (P for interaction=0.07), no association was found between egg consumption and cardiovascular disease risk among US cohorts (1.01, 0.96 to 1.06, I2=30.8%) or European cohorts (1.05, 0.92 to 1.19, I2=64.7%), but an inverse association was seen in Asian cohorts (0.92, 0.85 to 0.99, I2=44.8%).
Conclusions: Results from the three cohorts and from the updated meta-analysis show that moderate egg consumption (up to one egg per day) is not associated with cardiovascular disease risk overall, and is associated with potentially lower cardiovascular disease risk in Asian populations.
Systematic review registration: PROSPERO CRD42019129650.

First Authors:
Jean-Philippe Drouin-Chartier

Correspondence Authors:
Jean-Philippe Drouin-Chartier

All Authors:
Jean-Philippe Drouin-Chartier,Siyu Chen,Yanping Li,Amanda L Schwab,Meir J Stampfer,Frank M Sacks,Bernard Rosner,Walter C Willett,Frank B Hu,Shilpa N Bhupathiraju

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British Medical Journal期刊

Re: Egg consumption and risk of cardiovascular disease: three large prospective US cohort studies, systematic review, and updated meta-analysis

Victor W. Zhong,2020-03-06

点评:相关JAMA论文(https://www.mr-gut.cn/papers/read/1060256617)的第一兼通讯作者钟博士对本研究的回复和评论。

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