Nature子刊:常用药物与肠道菌群组成和代谢功能的关联
创作:mildbreeze 审核:mildbreeze 01月23日
  • 纳入普通队列和2个胃肠疾病队列共1883人,鉴定出19种常用药物与粪便宏基因组特征存在关联;
  • 例如:口服类固醇与炎症性肠病患者的史氏甲烷短杆菌增加相关,SSRI抗抑郁药与肠易激综合征患者的细枝真杆菌增加相关,二甲双胍与大肠杆菌和菌群代谢潜力变化相关;
  • 对同时服用多种药物进行校正后,质子泵抑制剂(PPI)、二甲双胍、抗生素和泻药与菌群组成和微生物通路的变化的关联性最强;
  • 15种药物的使用与菌群的抗生素耐药基因增加相关。
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mildbreeze
肠道菌群可影响药物效力,反过来药物也影响肠道菌群。Nature Communications发表的一项最新研究,对荷兰3个队列的数据进行了分析,鉴定出19种常用药物与肠道菌群特征的关联,重点列举了质子泵抑制剂、二甲双胍、SSRI抗抑郁药以及非抗生素药物与菌群变化的关联。这些发现对于研究药物-菌群互作有参考意义。
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Impact of commonly used drugs on the composition and metabolic function of the gut microbiota

常用药物对肠道菌群组成和代谢功能的影响

10.1038/s41467-019-14177-z

01-17, Article

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The human gut microbiota has now been associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. However, drug–microbe interactions are still understudied in the clinical context, where polypharmacy and comorbidities co-occur. Here, we report relations between commonly used drugs and the gut microbiome. We performed metagenomics sequencing of faecal samples from a population cohort and two gastrointestinal disease cohorts. Differences between users and non-users were analysed per cohort, followed by a meta-analysis. While 19 of 41 drugs are found to be associated with microbial features, when controlling for the use of multiple medications, proton-pump inhibitors, metformin, antibiotics and laxatives show the strongest associations with the microbiome. We here provide evidence for extensive changes in taxonomy, metabolic potential and resistome in relation to commonly used drugs. This paves the way for future studies and has implications for current microbiome studies by demonstrating the need to correct for multiple drug use.

First Authors:
Arnau Vich Vila

Correspondence Authors:
Rinse K Weersma

All Authors:
Arnau Vich Vila,Valerie Collij,Serena Sanna,Trishla Sinha,Floris Imhann,Arno R Bourgonje,Zlatan Mujagic,Daisy M A E Jonkers,Ad A M Masclee,Jingyuan Fu,A Kurilshikov,Cisca Wijmenga,Alexandra Zhernakova,Rinse K Weersma

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