刘学波+刘志刚+侯敏等:妈妈肥胖损伤孩子脑功能?补充膳食纤维或有益
创作:mildbreeze 审核:mildbreeze 04月01日
  • 纳入778名儿童,发现母亲孕前超重/肥胖与子女较差的认知和社交能力相关;
  • 小鼠试验中,高脂喂养导致的母体肥胖会引起后代的认知和社交行为缺陷,母体传给后代的肠道菌群在其中起介导作用;
  • 给肥胖母鼠或其后代补充膳食纤维(菊粉),可重塑母体传给后代的肠道菌群(如增加特定S24_7菌科OTU),改善后代的认知和行为缺陷以及海马区突触和剪接体的异常;
  • 口服补充菌群衍生物乙酸+丙酸,可改善肥胖母鼠后代的认知和社交行为缺陷。
主编推荐语
mildbreeze
生命早期“1000天”的营养健康状态,尤其是母亲的孕前和孕期健康对后代健康可造成深远影响。研究表明,母体肥胖可能增加后代的代谢疾病和认知缺陷的风险,但其生物学机制和干预方法仍待揭示。西北农林科技大学刘学波、刘志刚和上海交通大学侯敏与研究团队,最新在Cell Metabolism发表的一项重要研究表明,母体肥胖可引起后代的认知和社交行为缺陷,这些缺陷是由后代肠道菌群的变化引起的,而给母体或后代补充膳食纤维,可通过调节后代的肠道菌群组成及其代谢物短链脂肪酸来改善这些缺陷。该研究不仅揭示了母体肥胖影响后代神经发育的一种“菌群-代谢物-脑轴”机制,也为改善相关认知/行为缺陷提供了潜在的干预策略。
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Cell Metabolism [IF:21.567]

High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis

高纤维膳食通过肠-脑轴缓解母代肥胖引起的后代认知和社交障碍

10.1016/j.cmet.2021.02.002

03-01, Article

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Maternal obesity has been reported to be related to neurodevelopmental disorders in the offspring. However, the underlying mechanisms and effective interventions remain unclear. This cross-sectional study with 778 children aged 7–14 years in China indicated that maternal obesity is strongly associated with children’s lower cognition and sociality. Moreover, it has been demonstrated that maternal obesity in mice disrupted the behavior and gut microbiome in offspring, both of which were restored by a high-fiber diet in either dams or offspring via alleviating synaptic impairments and microglial maturation defects. Co-housing and feces microbiota transplantation experiments revealed a causal relationship between microbiota and behavioral changes. Moreover, treatment with the microbiota-derived short-chain fatty acids also alleviated the behavioral deficits in the offspring of obese dams. Together, our study indicated that the microbiota-metabolites-brain axis may underlie maternal obesity-induced cognitive and social dysfunctions and that high dietary fiber intake could be a promising intervention.

First Authors:
Xiaoning Liu,Xiang Li

Correspondence Authors:
Min Hou,Zhigang Liu,Xuebo Liu

All Authors:
Xiaoning Liu,Xiang Li,Bing Xia,Xin Jin,Qianhui Zou,Zhenhua Zeng,Weiyang Zhao,Shikai Yan,Ling Li,Shufen Yuan,Shancen Zhao,Xiaoshuang Dai,Fei Yin,Enrique Cadenas,Rui Hai Liu,Beita Zhao,Min Hou,Zhigang Liu,Xuebo Liu

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膳食纤维吃出健康?顶刊最新研究进展一览

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