华西第二医院:装载α-倒捻子素的多聚纳米颗粒抑制小鼠结直肠癌
创作:szx 审核:szx 2019年09月16日
  • 构建装载有α-倒捻子素的多聚纳米颗粒(α-M/PECE);
  • 在结直肠癌细胞系CT26及HCT116中,与游离的α-倒捻子素相比,α-M/PECE诱导的细胞凋亡显著增加;
  • 在皮下移植结直肠癌小鼠模型中,相比于游离的α-倒捻子素,α-M/PECE表现出更强的抑制肿瘤生长、肿瘤血管新生、肿瘤细胞增殖及诱导肿瘤细胞凋亡的能力;
  • 在肺部转移及腹部转移结直肠癌模型中,α-M/PECE表现出显著的抗转移疗效;
  • 游离的α-倒捻子素及α-M/PECE均未造成不良反应。
主编推荐语
szx
α-倒捻子素是山竹果皮中富含的一种氧杂蒽酮,对多种癌症具有潜在抗癌作用。来自四川大学华西第二医院的团队在Applied Materials Today上发表的一项最新研究,构建了一种装载有α-倒捻子素的多聚纳米颗粒,在体内及体外中均表现出显著的抗结直肠癌效应,并可抑制结直肠癌的转移。
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Polymeric nanoparticles encapsulating α-mangostin inhibit the growth and metastasis in colorectal cancer

装载α-倒捻子素的多聚纳米颗粒抑制结直肠癌的生长及转移

10.1016/j.apmt.2019.06.014

2019-07-19, Article

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α-Mangostin, the most abundant xanthone extracted from pericarp of mangosteen fruits, has been shown potential treatment effects in various cancer cell types. This led us to explore the anti-tumor activity and related mechanisms of α-mangostin in colorectal cancer. In this study, poly(ethylene glycol)–poly(e-caprolactone)–poly(ethylene glycol) (PEG–PCL–PEG, PECE) nanoparticles was used to encapsulate free α-mangostin, creating α-mangostin loaded PECE (α-M/PECE) nanoparticles. When compared with free α-mangostin, α-M/PECE induced a significantly more apoptosis of both CT26 and HCT116 cells in vitro, leading to an obviously more loss of mitochondrial membrane potential (Δψm) in HCT116 cells. Results of western blot assay and caspase-inhibiting assay showed that cell apoptosis induced by α-mangostin might via activating both death receptor-mediated caspase-8 pathway and mitochondrial dependent cytochrome c/caspase-9, with simultaneously regulating expression levels of Bcl-2 family proteins, and ultimately activating caspase-3. Moreover, the administration of α-M/PECE nanoparticles also exhibited significantly stronger inhibition in tumor growth, tumor angiogenesis, tumor cell proliferation as well as inducted more tumor cell apoptosis in subcutaneous xenograft models. Especially, α-M/PECE nanoparticles showed excellent anti-metastasis efficacy in both pulmonary metastasis model and abdominal metastasis model of colorectal cancer. The safety assessment also showed no obvious side effects were detected in mice which were treated with free α-mangostin or α-M/PECE nanoparticles. These results suggested the potential of α-M/PECE nanoparticles as an excellent intravenously injectable formulation of free α-mangostin for the treatment of colorectal cancer.

First Authors:
Ting Yu,Xi Huang,Jiagang Liu

Correspondence Authors:
Bilan Wang

All Authors:
Ting Yu,Xi Huang,Jiagang Liu,Qingyu Fu,Bilan Wang,Zhiyong Qian

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