Cell子刊:肠道不同位置感知不同营养成分从而调节进食行为
创作:阿当 审核:Zhonghua 02月01日
  • 下丘脑中包括AgRP神经元可以快速感知宏量营养素,调节动物进食行为;
  • 本研究建立小鼠小肠不同位置灌注营养素,检测下丘脑AgRP神经元钙信号的实验体系,以检测营养素调控进食信号传导通路;
  • 不同营养素在肠道不同位置被感知,经不同神经传输渠道与下丘脑神经元进行信号交流;
  • 脂肪主要于十二指肠感知,经迷走神经传输抑制AgRP神经元;
  • 葡萄糖感知依赖于SGLT1,其可经回肠感知,或吸收后经肝门静脉感知,经脊髓输入神经抑制AgRP神经元。
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Zhonghua
肠脑轴在调控动物进食,维持各种营养摄取和消耗的平衡中发挥重要的作用。目前,人们对于饱食后神经交互的研究较为清楚,然而对于动物摄食的过程中肠道营养信号是如何影响大脑中关键神经元的机制仍不明确。近期一篇发表在Cell子刊Cell Metabolism的研究工作建立了对小鼠不同肠道位置进行营养素灌注,检测下丘脑调节进食的关键神经元AgRP神经元钙信号的实验系统,结合神经传输阻断技术探究了宏量营养素脂肪、葡萄糖和氨基酸感知和神经传导通路,发现不同营养素在肠道的不同位置被感知,经不同的神经传导渠道与下丘脑神经元进行交互作用,为肠脑轴与摄食调控的研究提供了新的线索和证据。
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Cell Metabolism [IF:21.567]

Hypothalamic detection of macronutrients via multiple gut-brain pathways

下丘脑通过多种肠脑轴通道探测宏量营养素

10.1016/j.cmet.2020.12.018

01-14, Article

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Food intake is tightly regulated by complex and coordinated gut-brain interactions. Nutrients rapidly modulate activity in key populations of hypothalamic neurons that regulate food intake, including hunger-sensitive agouti-related protein (AgRP)-expressing neurons. Because individual macronutrients engage specific receptors in the gut to communicate with the brain, we reasoned that macronutrients may utilize different pathways to reduce activity in AgRP neurons. Here, we revealed that AgRP neuron activity in hungry mice is inhibited by site-specific intestinal detection of different macronutrients. We showed that vagal gut-brain signaling is required for AgRP neuron inhibition by fat. In contrast, spinal gut-brain signaling relays the presence of intestinal glucose. Further, we identified glucose sensors in the intestine and hepatic portal vein that mediate glucose-dependent AgRP neuron inhibition. Therefore, distinct pathways are activated by individual macronutrients to inhibit AgRP neuron activity.

First Authors:
Nitsan Goldstein

Correspondence Authors:
J Nicholas Betley,Amber L Alhadeff

All Authors:
Nitsan Goldstein,Aaron D McKnight,Jamie RE Carty,Myrtha Arnold,J Nicholas Betley,Amber L Alhadeff

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Cell Metabolism期刊

The nerve not taken

2021-03-02

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