Cell:未来趋势——个性化益生菌干预
  • 小鼠和人体中,消化道菌群存在梯度变化,粘膜和腔内的菌群存在差异,均不同于粪便菌群;
  • 益生菌通过消化道后在粪便中仍保持活性,但在小鼠肠粘膜的定殖受原有菌群的定殖抵抗;
  • 益生菌在人肠粘膜的定殖情况,有明显的个体、部位和菌株特异性,可将个体分为“易定殖”和“抗定殖”两类,并可对粘膜菌群组成/功能和人肠道基因表达产生短暂而不同的影响;
  • 干预前的宿主和菌群特征,而非干预期间粪便菌群变化,可预测益生菌的肠粘膜定殖。
主编推荐语
mildbreeze
益生菌被认为有益健康甚至能预防疾病,然而益生菌在肠粘膜的定殖情况仍待研究。Cell刚刚发表了来自以色列魏茨曼研究所两位Eran等主导的最新研究,分析了小鼠和人体消化道不同部位的样本,提出不应用粪便菌群来近似估计肠粘膜菌群。还通过多组学方法,着重分析了益生菌在人体肠粘膜的定殖情况和规律,及其对宿主的影响。这些结果表明,益生菌干预的效果可存在很大的个体间差异,因此个性化干预应是未来研究和转化应用的趋势。
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Cell [IF:66.85]

Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features

对经验性益生菌的个人化肠粘膜定殖抵抗与独特的宿主和微生物组特征相关

10.1016/j.cell.2018.08.041

2018-09-06, Article

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Empiric probiotics are commonly consumed by healthy individuals as means of life quality improvement and disease prevention. However, evidence of probiotic gut mucosal colonization efficacy remains sparse and controversial. We metagenomically characterized the murine and human mucosal-associated gastrointestinal microbiome and found it to only partially correlate with stool microbiome. A sequential invasive multi-omics measurement at baseline and during consumption of an 11-strain probiotic combination or placebo demonstrated that probiotics remain viable upon gastrointestinal passage. In colonized, but not germ-free mice, probiotics encountered a marked mucosal colonization resistance. In contrast, humans featured person-, region- and strain-specific mucosal colonization patterns, hallmarked by predictive baseline host and microbiome features, but indistinguishable by probiotics presence in stool. Consequently, probiotics induced a transient, individualized impact on mucosal community structure and gut transcriptome. Collectively, empiric probiotics supplementation may be limited in universally and persistently impacting the gut mucosa, meriting development of new personalized probiotic approaches.

First Authors:
Niv Zmora,Gili Zilberman-Schapira,Jotham Suez,Uria Mor

Correspondence Authors:
Zamir Halpern,Eran Segal,Eran Elinav

All Authors:
Niv Zmora,Gili Zilberman-Schapira,Jotham Suez,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Eran Kotler,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Yotam Cohen,Raquel Linevsky,Daphna Rothschild,Andreas E Moor,Shani Ben-Moshe,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Oren Shibolet,Hagit Shapiro,Meirav Pevsner-Fischer,Itai Sharon,Zamir Halpern,Eran Segal,Eran Elinav

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