黑猩猩肠道菌群多样性年龄变化模式与人类不同
  • 对乌干达基巴萊国家公园内166只8个月至67岁的野生黑猩猩肠道菌群进行长达3年的分析;
  • 黑猩猩肠道微生物的α多样性,组成,密度,个体间变化以及个体内随时间变化随年龄变化显著;
  • 与人类相似,黑猩猩婴儿肠道也有较高丰度的双歧杆菌,链球菌和拟杆菌等,且随年龄出现显著的个体内差异;
  • 但与人类不同,黑猩猩的肠道微生物多样性在婴儿期最高;
  • 人类和黑猩猩肠道菌群发育的不同轨迹反映出哺乳,饮食和免疫功能的种间差异。
主编推荐语
Zhonghua
灵长类动物的生存需要共生的肠道微生物的协同促进。这些微生物在发酵不可消化的植物物质,抵抗病原体,训练免疫系统中发挥重要的作用。人类在灵长类动物中是独一无二的,表现为人类需要高度可消化的食物,断奶早,成熟慢等,提示人与肠道微生物关系的轨迹可能不同于其他灵长类动物。近来一篇发表在Current Biology的研究通过对乌干达基巴莱国家公园的野生黑猩猩肠道菌群长达三年的分析,揭示了黑猩猩肠道菌群在不同个体、不同年龄之间的差异,发现尽管二者肠道菌群中存在一些相似的类群和丰度,但是不同于人类,黑猩猩婴儿期肠道菌群丰度最高。黑猩猩肠道菌随年龄变化模式与人类不同,反映出二者在哺乳、饮食和免疫功能的种间差异。
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Current Biology [IF:9.601]

Age Patterning in Wild Chimpanzee Gut Microbiota Diversity Reveals Differences from Humans in Early Life

野生黑猩猩肠道菌群多样性随年龄变化模式与人类不同

10.1016/j.cub.2020.10.075

2020-11-23, Article

Abstract & Authors:展开

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Survival in primates is facilitated by commensal gut microbes that ferment otherwise indigestible plant matter, resist colonization by pathogens, and train the developing immune system. However, humans are unique among primates in that we consume highly digestible foods, wean early, mature slowly, and exhibit high lifelong investments in maintenance. These adaptations suggest that lifetime trajectories of human-microbial relationships could differ from those of our closest living relatives. Here, we profile the gut microbiota of 166 wild chimpanzees aged 8 months to 67 years in the Kibale National Park, Uganda and compare the patterns of gut microbial maturation to those previously observed in humans. We found that chimpanzee gut microbial alpha-diversity, composition, density, interindividual variation, and within-individual change over time varied significantly with age. Notably, gut microbial signatures in infants <2 years old were distinct across all five metrics. Infant chimpanzee guts were enriched in some of the same taxa prevalent in infant humans (e.g., Bifidobacterium, Streptococcus, and Bacteroides), and chimpanzee gut microbial communities, like those of humans, exhibited higher interindividual variation in infancy versus later in life. However, in direct contrast to human infants, chimpanzee infants harbored surprisingly high-diversity rather than low-diversity gut bacterial communities compared with older conspecifics. These data indicate differential trajectories of gut microbiota development in humans and chimpanzees that are consistent with interspecific differences in lactation, diet, and immune function. Probing the phenotypic consequences of differential early-life gut microbial diversity in chimpanzees and other primates will illuminate the life history impacts of the hominid-microbiome partnership.

First Authors:
Aspen T Reese

Correspondence Authors:
Rachel N Carmody

All Authors:
Aspen T Reese,Sarah R Phillips,Leah A Owens,Emily M Venable,Kevin E Langergraber,Zarin P Machanda,John C Mitani,Martin N Muller,David P Watts,Richard W Wrangham,Tony L Goldberg,Melissa Emery Thompson,Rachel N Carmody

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Current Biology期刊

Microbiomes: Infant Chimps Crawling with Bacteria

2021-02-08

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