• 呼吸道流感病毒感染过程中,共生菌群调控病毒特异性CD4和CD8 T细胞的产生及抗体反应,抗生素处理可消除这种免疫反应;
  • 新霉素敏感细菌与肺部诱导的免疫反应有关;
  • 局部或远端注射TLR配体可减轻抗生素治疗小鼠的免疫损伤;
  • 完整的菌群提供信号,导致稳定状态的pro-IL-1b和pro-IL-18的mRNA表达;
  • 流感病毒感染后,炎症小体活化导致树突状细胞从肺部转移到引流淋巴结,启动T细胞;
  • 共生菌群通过激活炎症小体,从而调节呼吸道粘膜免疫。
PNAS [IF:9.58]

Microbiota regulates immune defense against respiratory tract influenza A virus infection



2011-03-14, Article

Abstract & Authors:展开

Although commensal bacteria are crucial in maintaining immune homeostasis of the intestine, the role of commensal bacteria in immune responses at other mucosal surfaces remains less clear. Here, we show that commensal microbiota composition critically regulates the generation of virus-specific CD4 and CD8 T cells and antibody responses following respiratory influenza virus infection. By using various antibiotic treatments, we found that neomycin-sensitive bacteria are associated with the induction of productive immune responses in the lung. Local or distal injection of Toll-like receptor (TLR) ligands could rescue the immune impairment in the antibiotic-treated mice. Intact microbiota provided signals leading to the expression of mRNA for pro-IL-1β and pro-IL-18 at steady state. Following influenza virus infection, inflammasome activation led to migration of dendritic cells (DCs) from the lung to the draining lymph node and T-cell priming. Our results reveal the importance of commensal microbiota in regulating immunity in the respiratory mucosa through the proper activation of inflammasomes.

First Authors:
Takeshi Ichinohe,Iris K Pang

Correspondence Authors:
Akiko Iwasaki

All Authors:
Takeshi Ichinohe,Iris K Pang,Yosuke Kumamoto,David R Peaper,John H Ho,Thomas S Murray,Akiko Iwasaki