地中海饮食与DASH饮食或可预防基底细胞癌
创作:szx 审核:szx 2020年06月08日
  • 对18424名受试者进行多年随访,通过问卷评估受试者的饮食情况,期间共发生101例基底细胞癌(BCC),选取与之相匹配的404例对照进行分析;
  • 相比于地中海饮食依从性最低的受试者,地中海饮食依从性最高的受试者的BCC风险显著降低72%;
  • 相比于DASH饮食评分最低的受试者,DASH饮食评分最高的受试者的BCC风险显著降低68%;
  • 素食(Pro-vegetarian)与BCC风险无显著关联;
  • 摄入更多的水果及低脂乳制品与更低的BCC风险显著相关。
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szx
American Journal of Clinical Nutrition上发表的一项巢式病例对照研究,对比101例基底细胞癌患者及404例年龄、性别等因素相匹配的对照,发现地中海饮食性越高,或DASH饮食评分越高,基底细胞癌风险越低,而素食与基底细胞癌风险并无显著关联。
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Mediterranean diet, Dietary Approaches to Stop Hypertension, and Pro-vegetarian dietary pattern in relation to the risk of basal cell carcinoma: a nested case-control study within the Seguimiento Universidad de Navarra (SUN) cohort

地中海饮食、DASH饮食及素食与基底细胞癌风险的关联:一项巢式病例对照研究

10.1093/ajcn/nqaa127

2020-06-03, Article

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Background: The association of dietary pattern with the risk of basal cell carcinoma (BCC) is little understood and has scarcely been investigated.
Objectives: We assessed the association of several complete dietary patterns [Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Pro-vegetarian dietary pattern] with the risk of BCC, conducting a nested case-control study (4 controls for each case).
Methods: Cases and controls were selected from the SUN (Seguimiento Universidad de Navarra) cohort using risk set sampling. Cases were identified among subjects free of skin cancer at baseline but who later reported a physician-made BCC diagnosis during the follow-up period. In the cohort we identified 101 incident cases of BCC.
Results: In multivariable-adjusted conditional logistic regression analyses, better adherence to the Mediterranean diet (highest compared with lowest quintile) was associated with a 72% relative reduction in the odds of BCC (OR: 0.28; 95% CI: 0.10, 0.77; Ptrend = 0.014); the DASH diet was associated with a 68% RR reduction (OR: 0.32; 95% CI: 0.14, 0.76; Ptrend = 0.013) for the comparison between extreme quintiles. No association was found between a Pro-vegetarian dietary pattern and BCC. Higher fruit consumption (highest compared with lowest quintile, OR: 0.27; 95% CI: 0.11, 0.64; Ptrend < 0.001) and low-fat dairy products (OR: 0.39; 95% CI: 0.16, 0.92; Ptrend = 0.014) were associated with a lower BCC risk.
Conclusions: Our results suggest that Mediterranean and DASH dietary patterns may be associated with a lower risk of BCC, but confirmatory studies are required.

First Authors:
Alessandro Leone

Correspondence Authors:
Alessandro Leone

All Authors:
Alessandro Leone,Miguel Á Martínez-González,Alejandro Martin-Gorgojo,Rodrigo Sánchez-Bayona,Ramona De Amicis,Simona Bertoli,Alberto Battezzati,Maira Bes-Rastrollo

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