JAMA子刊:父亲抑郁或对女儿成长有影响
创作:Epi汪 审核:Epi汪 2019年05月10日
  • 纳入英国基于社区的前瞻性出生队列中3176对父亲和婴儿,父亲平均年龄29.6岁;
  • 评估父/母亲在新生儿产后8周、8月时抑郁症状、夫妻冲突,以及婴儿在42个月时行为问题,并评估其18岁时抑郁症状;
  • 父亲在产后有抑郁症状将增大女儿18岁时抑郁的风险,在男孩中的关联无统计学意义;
  • 在此关联中,母亲产后8个月的抑郁症状、婴儿42月时的行为问题均起到中介作用,分别可解释21%和7.5%的关联;
  • 父亲在产后的抑郁症状在儿童成长中也有潜在影响。
主编推荐语
Epi汪
母亲产后抑郁是围产科常见的问题之一,已有研究表明其可能影响后代的精神发育,增大抑郁风险。本研究关注在婴儿出生后父亲的抑郁症状与后代18岁时抑郁的关联。发现父亲抑郁更能增加女儿的抑郁风险,其机制可能是通过母亲抑郁症状以及42月时婴儿的行为问题所导致。父母亲是婴儿早期成长发育过程中不可或缺的因素,当任何一方有抑郁症状时,应引起足够的重视。
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JAMA Psychiatry [IF:21.596]

Association of Maternal and Paternal Depression in the Postnatal Period With Offspring Depression at Age 18 Years

产后父母亲的抑郁症状与后代18岁时抑郁症状之间的关联

10.1001/jamapsychiatry.2018.3667

2018-12-26, Article

Abstract & Authors:展开

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Importance: Paternal depression during the postnatal period has been associated with adverse child outcomes. Family environment has been reported as a pathway for risk transmission from fathers to children. The influence of paternal depression during the postnatal period on offspring depression remains to be clarified.
Objective: To investigate the association between paternal depression in the postnatal period and offspring depression and explore potential mediating and moderating factors that influence any association between paternal and offspring depression.
Design, Setting, and Participants: This prospective study of a UK community-based birth cohort (the Avon Longitudinal Study of Parents and Children) of parents and their adolescent offspring investigated associations between paternal depression during the postnatal period and offspring depression at age 18 years. We tested a hypothesized moderator (ie, sex) and conducted path analysis to examine hypothesized mediators (ie, depression in the other parent, couple conflict, and paternal involvement and emotional problems, conduct problems, and hyperactivity in offspring at age 3.5 years) of the associations between both paternal and maternal depression and offspring depression. Data collection for the Avon Longitudinal Study of Parents and Children began in 1991 and is ongoing. Data analysis for this study was conducted from June 2015 to September 2018.
Exposures: Depression symptoms in fathers at 8 weeks after the birth of their children.
Main Outcomes and Measures: Offspring depression symptoms at age 18 years, using International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes.
Results: A total of 3176 father-offspring pairs were analyzed; of the children, 1764 were girls (55.5%) and 1412 (44.5%) were boys. Paternal mean (SD) age at delivery was 29.6 (9.6) years. The offspring of fathers who had depression during the postnatal period were at increased risk of experiencing depression symptoms at age 18 years (β = 0.053 [95% CI, 0.02-0.09]). The association is mediated by maternal depression at 8 months after birth (β = 0.011 [95% CI, 0.0008-0.02]; 21% [0.011/0.053]) and conduct problems at 42 months after birth (β = 0.004; [95% CI , -0.00004 to 0.009]; 7.5% [0.004/0.053]). Couple conflict and paternal involvement do not mediate this association. The increased risk is seen in girls but not boys (interaction β = 0.095; P = .01).
Conclusions and Relevance: The association between paternal depression in the postnatal period and depression in girls at age 18 years is partially explained by maternal depression. Couple conflict and paternal involvement were not found to play a role in the risk of transmission; this contrasts with the role that couple conflict was found to play in the risk of childhood behavior problems. Conduct problems in childhood appear to be a pathway for risk transmission between paternal depression and subsequent depression in offspring at age 18 years.

First Authors:
Leticia Gutierrez-Galve

Correspondence Authors:
Paul G Ramchandani

All Authors:
Leticia Gutierrez-Galve,Alan Stein,Lucy Hanington,Jon Heron,Glyn Lewis,Christine O'Farrelly,Paul G Ramchandani

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