解析肠神经网络与肠道运动
创作:女巫 审核:周旸 2019年03月19日
  • 使用钙离子成像技术,可确定在局灶性网络刺激下大量肠道神经元的位置和反应特定;
  • 通过神经元追踪和突触重建方法,发现肠神经元及神经网络的分布具有组织区域特异性,运动方式越复杂的肠道区域神经网络也越复杂;
  • 远端结肠以蠕动为主,与之相比,运动模式多样化的近端结肠需要额外神经回路元件;
  • 肠神经网络对运动的控制模式是固定的,神经回路的复杂性与特定肠区域的运动模式是匹配的。
主编推荐语
周旸
肠神经系统控制着包括肠蠕动在内的多种胃肠功能。《eLife》近期发表研究,利用钙离子成像、神经元追踪和突触重建等方法,发现发现肠神经元及神经网络的分布具有组织区域特异性,神经网络的复杂程度与运动方式相匹配。该结果对阐释肠神经功能、肠道运动机制具有参考价值。
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eLife [IF:7.08]

Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine

肠道神经元连接的区域复杂性反映了小鼠大肠运动模式的多样性

10.7554/eLife.42914

2019-02-12, Article

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The enteric nervous system controls a variety of gastrointestinal functions including intestinal motility. The minimal neuronal circuit necessary to direct peristalsis is well-characterized but several intestinal regions display also other motility patterns for which the underlying circuits and connectivity schemes that coordinate the transition between those patterns are poorly understood. We investigated whether in regions with a richer palette of motility patterns, the underlying nerve circuits reflect this complexity. Using Ca imaging, we determined the location and response fingerprint of large populations of enteric neurons upon focal network stimulation. Complemented by neuronal tracing and volumetric reconstructions of synaptic contacts, this shows that the multifunctional proximal colon requires specific additional circuit components as compared to the distal colon, where peristalsis is the predominant motility pattern. Our study reveals that motility control is hard-wired in the enteric neural networks and that circuit complexity matches the motor pattern portfolio of specific intestinal regions.

First Authors:
Zhiling Li

Correspondence Authors:
Pieter Vanden Berghe

All Authors:
Zhiling Li,Marlene M Hao,Chris Van den Haute,Veerle Baekelandt,Werend Boesmans,Pieter Vanden Berghe

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