短期西式饮食引发肠道菌群紊乱,促发炎症
创作:orchid 审核:兵兵 02月04日
  • IL-23微循环小鼠高糖中脂饮食(即西式饮食,WD)10周,皮肤和关节出现发炎症状;
  • WD引起的皮肤和关节损伤与产生IL-17A的γδT细胞的增殖和Th17细胞因子的表达增加有关;
  • 喂食WD的IL-23介导小鼠肠道菌群多样性降低,并出现明显的菌群失调;
  • 广谱抗生素治疗抑制了WD喂养的IL-23介导小鼠的皮肤和关节炎症;
  • IL-23介导小鼠从WD转变为标准饮食时,皮肤和关节炎症减少,肠道菌群失调部分逆转。
  • WD引发肠道菌群紊乱,促发银屑病皮肤和关节炎。
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文章探究了西式饮食对IL-23介导小鼠皮肤、关节炎症的影响。研究结果显示,西式饮食模式可以促发IL-23小鼠炎症,并且该现象与肠道菌群有关。
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Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice

短期西方饮食摄入促进IL-23介导的小鼠皮肤和关节炎症,并伴随肠道菌群的改变

10.1016/j.jid.2020.11.032

01-21, Article

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We previously showed that exposure to a high-sugar and moderate-fat diet (i.e., Western diet, WD) in mice induces appreciable skin inflammation and enhances the susceptibility to imiquimod-induced psoriasiform dermatitis (PsD), suggesting that dietary components may render the skin susceptible to psoriatic inflammation. Herein, utilizing an IL-23 minicircle (MC)-based model with features of both PsD and psoriatic arthritis (PsA), we showed that intake of WD for 10 weeks predisposed mice not only to skin but also joint inflammation. Both WD-induced skin and joint injuries were associated with an expansion of IL-17A-producing γδ T cells and increased expression of Th17 cytokines. After IL-23 MC delivery, WD-fed mice had reduced microbial diversity and pronounced dysbiosis. Treatment with broad-spectrum antibiotics suppressed IL-23-mediated skin and joint inflammation in WD-fed mice. Strikingly, reduced skin and joint inflammation with a partial reversion of the gut microbiota were noted when mice switched from a WD to a standard diet after IL-23 MC delivery. These findings reveal that short-term WD intake-induced dysbiosis is accompanied by enhanced psoriasis-like skin and joint inflammation. Modifications toward a healthier dietary pattern should be considered in patients with psoriatic skin and/or joint disease.

First Authors:
Zhenrui Shi

Correspondence Authors:
Samuel T Hwang

All Authors:
Zhenrui Shi,Xuesong Wu,Clarissa Santos Rocha,Matthew Rolston,Emma Garcia-Melchor,Mindy Huynh,Mimi Nguyen,Timothy Law,Kelly N Haas,Daisuke Yamada,Neal L Millar,Yu-Jui Yvonne Wan,Satya Dandekar,Samuel T Hwang

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