Nature子刊:大肠癌细胞基因表达影响免疫全景
创作:Lexi 审核:Lexi 05月29日
  • 分析来自29位结直肠癌(CRC)患者的91103个单细胞转录组;
  • 与正常组织相比,肿瘤组织中髓系细胞增多,B细胞减少;
  • 致癌事件与细胞世系相关,肿瘤微环境和瘤内异质性决定癌细胞的转录特征,其转录特征与正常分化程序相似;
  • 周皮细胞、肌成纤维细胞、内皮细胞等基质细胞支持肿瘤生长;
  • 癌细胞基因改变促进调节性T细胞、肌成纤维细胞和骨髓细胞介导的免疫抑制微环境形成;
  • 细胞间网络重建支持癌细胞特征与特定间质或免疫细胞群的联系。
主编推荐语
Lexi
转移性结直肠癌(CRC)的免疫治疗只对高微卫星不稳定的错配修复缺陷肿瘤有效,后者表现出较高免疫浸润。由此推测,肿瘤细胞能塑造其免疫微环境。最新发表在Nature Genetics的研究分析了来自CRC患者的单细胞转录组,揭示了癌细胞与免疫细胞、基质细胞的联系,为肿瘤免疫治疗策略提供理论基础。
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Nature Genetics [IF:27.603]

Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

依赖世系的基因表达程序影响结直肠癌免疫全景

10.1038/s41588-020-0636-z

05-25, Article

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Abstract:收起
Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient tumors with high microsatellite instability that demonstrate immune infiltration, suggesting that tumor cells can determine their immune microenvironment. To understand this cross-talk, we analyzed the transcriptome of 91,103 unsorted single cells from 23 Korean and 6 Belgian patients. Cancer cells displayed transcriptional features reminiscent of normal differentiation programs, and genetic alterations that apparently fostered immunosuppressive microenvironments directed by regulatory T cells, myofibroblasts and myeloid cells. Intercellular network reconstruction supported the association between cancer cell signatures and specific stromal or immune cell populations. Our collective view of the cellular landscape and intercellular interactions in colorectal cancer provide mechanistic information for the design of efficient immuno-oncology treatment strategies.

First Authors:
Hae-Ock Lee,Yourae Hong,Hakki Emre Etlioglu,Yong Beom Cho

Correspondence Authors:
Sabine Tejpar,Woong-Yang Park

All Authors:
Hae-Ock Lee,Yourae Hong,Hakki Emre Etlioglu,Yong Beom Cho,Valentina Pomella,Ben Van den Bosch,Jasper Vanhecke,Sara Verbandt,Hyekyung Hong,Jae-Woong Min,Nayoung Kim,Hye Hyeon Eum,Junbin Qian,Bram Boeckx,Diether Lambrechts,Petros Tsantoulis,Gert De Hertogh,Woosung Chung,Taeseob Lee,Minae An,Hyun-Tae Shin,Je-Gun Joung,Min-Hyeok Jung,Gunhwan Ko,Pratyaksha Wirapati,Seok Hyung Kim,Hee Cheol Kim,Seong Hyeon Yun,Iain Bee Huat Tan,Bobby Ranjan,Woo Yong Lee,Tae-You Kim,Jung Kyoon Choi,Young-Joon Kim,Shyam Prabhakar,Sabine Tejpar,Woong-Yang Park

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