中山大学:间歇性禁食改善代谢综合征的心血管风险因素和肠道菌群
  • 招募39名代谢综合征(MS)患者,随机分成间歇性禁食组(IF)和对照组,IF组在禁食日要比不禁食日减少69%的热量摄入;
  • 8周后,IF组显著降低脂肪含量,改善氧化应激,调控炎症细胞因子,改善血管舒张参数,不影响血脂、葡萄糖代谢或血压;
  • IF诱导肠道微生物群落发生显著变化,增加短链脂肪酸(SCFAs)的产生,降低循环性脂多糖的水平;
  • IF组的肠道菌群改变与心血管风险因素显著相关,并导致肠道菌群的碳水化合物代谢途径发生明显变化。
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爱的抉择
中山大学夏敏团队在Journal of Clinical Endocrinology and Metabolism上发表文章,揭示出间歇性禁食一定程度上引起代谢综合征患者肠道微生物群落和功能途径的显著改变,这与心脏代谢风险因素的缓解密切相关。研究或为预防代谢综合征相关的不良后果提供了潜在机制。
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Intermittent Fasting Improves Cardiometabolic Risk Factors and Alters Gut Microbiota in Metabolic Syndrome Patients

间歇性禁食改善代谢综合征患者的心脏代谢危险因素并改变肠道菌群

10.1210/clinem/dgaa644

2020-10-06, Article

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Context: Intermittent fasting (IF) is an effective strategy to the improvement of cardiometabolic health.
Objective: To examine the effects of IF on cardiometabolic risk factors and the gut microbiota in patients with metabolic syndrome (MS).
Design: Randomized clinical trial.
Patients: Adults with MS, 30-50 years of age.
Intervention: 8 weeks of “two-day” modified IF.
Main Outcome Measure: Cardiometabolic risk factors including body composition, oxidative stress, inflammatory cytokines, and endothelial function were assessed at baseline and 8 weeks. The diversity, composition, and functional pathways of the gut microbiota, as well as circulating gut-derived metabolites were also measured.
Results: 39 patients with MS were included: 21 in the IF group and 18 in the control group. On fasting days, participants in the IF group reduced 69% of the calorie intake compared to nonfasting days. The 8-week IF significantly reduced fat mass, ameliorated oxidative stress, modulated inflammatory cytokines, and improved the vasodilatory parameters. Furthermore, IF induced significant changes in gut microbiota communities, increased the production of short-chain fatty acids (SCFAs), and decreased the circulating levels of lipopolysaccharides (LPS). Gut microbiota alteration attributed to the IF was significantly associated with cardiovascular risk factors and resulted in distinct genetic shifts of carbohydrate metabolism in the gut community.
Conclusion: IF induces a significant alteration of the gut microbial community and functional pathways in a manner, which is closely associated with the mitigation of cardiometabolic risk factors. The study provides potential mechanistic insights into the prevention of adverse outcomes associated with MS.

First Authors:
Yi Guo

Correspondence Authors:
Min Xia

All Authors:
Yi Guo,Shiyun Luo,Yongxin Ye,Songping Yin,Jiahua Fan,Min Xia

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