Nature子刊:两种乳杆菌或能改善“吃出来”的糖尿病
创作:mildbreeze 审核:mildbreeze 01月08日
  • 通过数据驱动的方法(跨界网络分析)建模西式饮食(WD)下的宿主-微生物组互作,鉴定出若干种对小鼠宿主糖脂代谢有潜在益处或害处的肠道细菌;
  • 在肥胖人群中也存在上述细菌-代谢关联性;
  • 给WD小鼠补充这几种细菌,虽未显著改变菌群,但能通过不同的宿主途径影响宿主代谢;
  • 其中,两种乳杆菌(约氏、格氏)能提高血液中的还原型谷胱甘肽水平,从而改善肝脏的线粒体形态和功能,减少肝脏脂质、改善系统性的糖代谢。
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mildbreeze
西式饮食(WD)是导致包括2型糖尿病(T2D)在内的代谢性疾病的主要原因之一,肠道菌群在其中有潜在重要作用。Nature Communications近期发表的一项研究发现,WD对机体代谢的损害至少可以在一定程度上是由肠道菌群中的有益细菌(如约氏和格式乳杆菌)减少和致病菌(如Romboutsia ilealis)增多造成的,为改善饮食诱导的T2D提供了潜在的益生菌菌株,并揭示了其作用机制。
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Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes

乳酸菌与肝线粒体之间的跨界相互作用可减轻西式饮食引起的糖尿病

10.1038/s41467-020-20313-x

01-04, Article

Abstract & Authors:展开

Abstract:收起
Western diet (WD) is one of the major culprits of metabolic disease including type 2 diabetes (T2D) with gut microbiota playing an important role in modulating effects of the diet. Herein, we use a data-driven approach (Transkingdom Network analysis) to model host-microbiome interactions under WD to infer which members of microbiota contribute to the altered host metabolism. Interrogation of this network pointed to taxa with potential beneficial or harmful effects on host’s metabolism. We then validate the functional role of the predicted bacteria in regulating metabolism and show that they act via different host pathways. Our gene expression and electron microscopy studies show that two species from Lactobacillus genus act upon mitochondria in the liver leading to the improvement of lipid metabolism. Metabolomics analyses revealed that reduced glutathione may mediate these effects. Our study identifies potential probiotic strains for T2D and provides important insights into mechanisms of their action.

First Authors:
Richard R Rodrigues,Manoj Gurung,Zhipeng Li

Correspondence Authors:
Andrey Morgun,Natalia Shulzhenko

All Authors:
Richard R Rodrigues,Manoj Gurung,Zhipeng Li,Manuel García-Jaramillo,Renee Greer,Christopher Gaulke,Franziska Bauchinger,Hyekyoung You,Jacob W Pederson,Stephany Vasquez-Perez,Kimberly D White,Briana Frink,Benjamin Philmus,Donald B Jump,Giorgio Trinchieri,David Berry,Thomas J Sharpton,Amiran Dzutsev,Andrey Morgun,Natalia Shulzhenko

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