分娩方式和孕期饮食可影响婴儿肠道菌群
  • 分析145个6周龄婴儿的肠道菌群与母亲孕期饮食和分娩方式的关系;
  • 阴道分娩的婴儿肠道菌群可分为三类,分别富含双歧杆菌属、链球菌属/梭菌属、拟杆菌属,孕期水果摄入增多,可增加婴儿划入第二类菌群的几率;
  • 剖腹产婴儿的肠道菌群也可分为三类,分别富含双歧杆菌属、梭菌属(链球菌属和瘤胃球菌属较少)、肠杆菌科,孕期乳制品摄入与婴儿梭菌属含量高相关;
  • 孕期鱼和海鲜摄入与婴儿的链球菌属丰度正相关。
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Microbiome刚刚上线的一项研究分析了分娩方式和孕期饮食对婴儿肠道菌群的影响,发现特定饮食成分(水果、海鲜、乳制品等)和营养元素可影响婴儿肠道中特定类型细菌的含量,而这些影响在不同分娩模式中存在差异。
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Microbiome [IF:11.607]

Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner

孕期母体饮食以依赖于分娩方式的形式与婴儿粪便菌群有关

10.1186/s40168-018-0490-8

2018-07-05, Article

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Background: The gut microbiome has an important role in infant health and immune development and may be affected by early-life exposures. Maternal diet may influence the infant gut microbiome through vertical transfer of maternal microbes to infants during vaginal delivery and breastfeeding. We aimed to examine the association of maternal diet during pregnancy with the infant gut microbiome 6 weeks post-delivery in mother-infant dyads enrolled in the New Hampshire Birth Cohort Study. Infant stool samples were collected from 145 infants, and maternal prenatal diet was assessed using a food frequency questionnaire. We used targeted sequencing of the 16S rRNA V4-V5 hypervariable region to characterize infant gut microbiota. To account for differences in baseline and trajectories of infant gut microbial profiles, we stratified analyses by delivery mode.
Results: We identified three infant gut microbiome clusters, characterized by increased abundance of Bifidobacterium, Streptococcus and Clostridium, and Bacteroides, respectively, overall and in the vaginally delivered infant stratum. In the analyses stratified to infants born vaginally and adjusted for other potential confounders, maternal fruit intake was associated with infant gut microbial community structure (PERMANOVA, p < 0.05). In multinomial logistic regression analyses, increased fruit intake was associated with an increased odds of belonging to the high Streptococcus/Clostridium group among infants born vaginally (OR (95% CI) = 2.73 (1.36, 5.46)). In infants delivered by Cesarean section, we identified three clusters that differed slightly from vaginally delivered infants, which were characterized by a high abundance of Bifidobacterium, high Clostridium and low Streptococcus and Ruminococcus genera, and high abundance of the family Enterobacteriaceae. Maternal dairy intake was associated with an increased odds of infants belonging to the high Clostridium cluster in infants born by Cesarean section (OR (95% CI) = 2.36 (1.05, 5.30)). Linear models suggested additional associations between maternal diet and infant intestinal microbes in both delivery mode strata.
Conclusions: Our data indicate that maternal diet influences the infant gut microbiome and that these effects differ by delivery mode.

First Authors:
Sara N Lundgren

Correspondence Authors:
Anne G Hoen

All Authors:
Sara N Lundgren,Juliette C Madan,Jennifer A Emond,Hilary G Morrison,Brock C Christensen,Margaret R Karagas,Anne G Hoen

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