肠道菌群调节5-羟色胺影响焦虑行为
  • 压力改变肠道菌群,影响压力激素和脑源性神经营养因子(BDNF),可引起焦虑行为;
  • 肠道中产生的5-羟色胺是一种激素和兴奋性神经递质,在焦虑和抑郁中有重要作用,菌群可调控其在血液和大脑中的水平;
  • 无菌小鼠大脑海马区5-羟色胺及其代谢物5-HIAA、血液色氨酸水平均上升,BDNF和色氨酸代谢生成的犬尿氨酸减少;
  • 菌群介导了海马区5-羟色胺、5-HIAA、BDNF和血液色氨酸的性别差异;
  • 幼年期肠道菌群可影响海马区神经发生等神经发育过程。
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mildbreeze
肠道菌群可调节神经递质5-羟色胺来影响焦虑样行为,Trends in Neurosciences近期发表一篇短文,梳理了近20年的相关研究进展,重点回顾了2013年Clarke等人的研究,对肠脑轴感兴趣的人不妨用这篇文章入门。
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Linking the Gut Microbiota to a Brain Neurotransmitter

将肠道菌群与一种大脑神经递质联系起来

10.1016/j.tins.2018.04.001

2018-07-01, Editorial Material

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The past decade has yielded substantial evidence that the gut microbiome modulates brain function, including for instance behaviors relevant to anxiety and depression, pointing to a need to identify the biological pathways involved. In 2013 Clarke and colleagues reported that the early-life microbiome regulates the hippocampal serotonergic system in a sex-dependent manner, findings that opened up numerous lines of inquiry on the effects of the microbiome on neurodevelopment and behavior.

First Authors:
Kelly G Jameson

Correspondence Authors:
Kelly G Jameson

All Authors:
Kelly G Jameson,Elaine Hsiao

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