益生菌抗焦虑?还不能定论
创作:szx 审核:szx 2018年06月26日
  • 纳入22项临床前研究(共743只动物)及14项临床试验(1527名受试者)进行荟萃分析,分析益生菌在抗焦虑中的作用;
  • 总体上,益生菌显著减少了动物的焦虑样行为,亚组分析显示益生菌仅减少了疾病(包括高血氨症、DSS诱导结肠炎等)动物的焦虑样行为;
  • 在物种水平的益生菌分析揭示,仅有鼠李糖乳杆菌具有抗焦虑作用;
  • 在人体试验中,益生菌并未显著减少焦虑症状,并且在健康人及患者(包括IBS、癌症、情绪低落)中均无抗焦虑作用。
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szx
PLoS ONE上发表的一项荟萃分析,纳入22项在动物模型中的临床前研究及14项临床试验,发现在人体研究中,益生菌并未表现出显著的抗焦虑作用。
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PLoS ONE [IF:2.74]

The anxiolytic effect of probiotics: A systematic review and meta-analysis of the clinical and preclinical literature

益生菌的抗焦虑作用:临床试验及临床前研究的系统性综述与荟萃分析

10.1371/journal.pone.0199041

2018-06-20, Review

Abstract & Authors:展开

Abstract:收起
BACKGROUND: Probiotics have generated intensive research interest in recent years as a novel mode of treatment for physical and mental illness. Nevertheless, the anxiolytic potential of probiotics remains unclear. The present systematic review and meta-analysis aimed to evaluate the clinical and preclinical (animal model) evidence regarding the effect of probiotic administration on anxiety.
METHODS: The PubMed, PsycINFO, and Web of Science databases were reviewed for preclinical and clinical studies that met the defined inclusion and exclusion criteria. The effects of probiotics on anxiety-like behavior and symptoms of anxiety were analyzed by meta-analyses. Separate subgroup analyses were conducted on diseased versus healthy animals, specific preclinical probiotic species, and clinical versus healthy human samples.
RESULTS: Data were extracted from 22 preclinical studies (743 animals) and 14 clinical studies (1527 individuals). Overall, probiotics reduced anxiety-like behavior in animals (Hedges' g = -0.47, 95% CI -0.77 --0.16, p = 0.004). Subgroup analyses revealed a significant reduction only among diseased animals. Probiotic species-level analyses identified only Lactobacillus (L.) rhamnosus as an anxiolytic species, but these analyses were broadly under-powered. Probiotics did not significantly reduce symptoms of anxiety in humans (Hedges' g = -0.12, 95% CI -0.29-0.05, p = 0.151), and did not differentially affect clinical and healthy human samples.
CONCLUSIONS: While preclinical (animal) studies suggest that probiotics may help reduce anxiety, such findings have not yet translated to clinical research in humans, perhaps due to the dearth of extant research with clinically anxious populations. Further investigation of probiotic treatment for clinically relevant anxiety is warranted, particularly with respect to the probiotic species L. rhamnosus.

First Authors:
Daniel J Reis

Correspondence Authors:
Daniel J Reis

All Authors:
Daniel J Reis,Stephen S Ilardi,Stephanie E W Punt

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