Science子刊:生酮饮食或可对抗流感病毒感染
创作:szx 审核:szx 2019年11月26日
  • 在甲型流感病毒感染7天前,给小鼠喂食生酮饮食,可显著提高小鼠的生存率及体重;
  • 机制上,生酮饮食显著增加了小鼠肺部的γδ T细胞,并增强了肺部的屏障功能;
  • 仅保留生酮饮食中的高脂饮食部分(喂食高脂饮食+高碳水化合物饮食)、或直接喂食酮体底物(绕过肝脏生酮作用),均无法诱导保护性γδ T细胞的产生;
  • 上述结果提示,保护性γδ T细胞的扩增需要小鼠对生酮饮食的代谢适应。
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szx
Science Immunology上发表的一项最新研究,发现给小鼠喂食生酮饮食,可通过增加肺部的γδ T细胞并增强肺部屏障功能,提升小鼠对甲型流感病毒的抵抗力。
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Science Immunology [IF:13.44]

Ketogenic diet activates protective γδ T cell responses against influenza virus infection

生酮饮食激活针对流感病毒感染的保护性γδ T细胞应答

10.1126/sciimmunol.aav2026

2019-11-15, Report

Abstract & Authors:展开

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Influenza A virus (IAV) infection–associated morbidity and mortality are a key global health care concern, necessitating the identification of new therapies capable of reducing the severity of IAV infections. In this study, we show that the consumption of a low-carbohydrate, high-fat ketogenic diet (KD) protects mice from lethal IAV infection and disease. KD feeding resulted in an expansion of γδ T cells in the lung that improved barrier functions, thereby enhancing antiviral resistance. Expansion of these protective γδ T cells required metabolic adaptation to a ketogenic diet because neither feeding mice a high-fat, high-carbohydrate diet nor providing chemical ketone body substrate that bypasses hepatic ketogenesis protected against infection. Therefore, KD-mediated immune-metabolic integration represents a viable avenue toward preventing or alleviating influenza disease.

First Authors:
Emily L Goldberg

Correspondence Authors:
Vishwa Deep Dixit,Akiko Iwasaki

All Authors:
Emily L Goldberg,Ryan D Molony,Eriko Kudo,Sviatoslav Sidorov,Yong Kong,Vishwa Deep Dixit,Akiko Iwasaki

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