Nature Reviews:合生制剂是什么?该怎么研究?(ISAPP共识声明)
  • 合生制剂是指“由活的微生物(M)和能被宿主微生物(包括宿主原有的和补充的)选择性利用的底物(S)组成的混合物,可为宿主带来健康益处”;
  • 可分为互补型和协同型,都需在目标宿主中验证健康功效;
  • 互补型合生制剂包含益生菌+益生元,而协同型中的M和S无须是益生菌/元,但共同使用时S应能被M选择性利用,以增强其功能;
  • 合生制剂研究应注意RCT设计、受试人群、干预方法、对照、对健康和菌群的作用、数据统计、安全性等细节。
主编推荐语
mildbreeze
长期以来,人们对于合生制剂(synbiotics)的认识就是益生菌+益生元的混合物。但是随着对肠道菌群和相关干预方法的不断研究,合生制剂的概念也在发生变化。国际益生菌和益生元科学协会(ISAPP)于2019年5月召开讨论会,对合生制剂的定义和范围进行了深入探讨,并于近期在Nature Reviews Gastroenterology and Hepatology发表了共识声明,对合生制剂的定义、类型等概念进行了更新,并对相关研究注意事项提出了细节建议。这些内容不仅对科研人员具有指导意义,对于利益相关者、监管机构、产业和媒体也有重要参考价值。
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The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics

国际益生菌和益生元科学协会(ISAPP)对合生制剂的定义和范围的共识声明

10.1038/s41575-020-0344-2

2020-08-21, Other

Abstract & Authors:展开

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In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to “a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host”. The panel concluded that defining synbiotics as simply a mixture of probiotics and prebiotics could suppress the innovation of synbiotics that are designed to function cooperatively. Requiring that each component must meet the evidence and dose requirements for probiotics and prebiotics individually could also present an obstacle. Rather, the panel clarified that a complementary synbiotic, which has not been designed so that its component parts function cooperatively, must be composed of a probiotic plus a prebiotic, whereas a synergistic synbiotic does not need to be so. A synergistic synbiotic is a synbiotic for which the substrate is designed to be selectively utilized by the co-administered microorganisms. This Consensus Statement further explores the levels of evidence (existing and required), safety, effects upon targets and implications for stakeholders of the synbiotic concept.

First Authors:
Kelly S Swanson

Correspondence Authors:
Kelly S Swanson

All Authors:
Kelly S Swanson,Glenn R Gibson,Robert Hutkins,Raylene A Reimer,Gregor Reid,Kristin Verbeke,Karen P Scott,Hannah D Holscher,Meghan B Azad,Nathalie M Delzenne,Mary Ellen Sanders

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ScienceDaily新闻网站

Global gut health experts guide growth of synbiotics

2020-08-24

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