国内团队:斑马鱼肠道菌群的生态演替
创作:lzm 审核:solo 02月04日
  • 构建三种不同的水环境,研究宿主因素和环境对斑马鱼肠道菌群最初定殖和随后演替的影响;
  • 环境不变,斑马鱼肠道菌群显示发育阶段模式特异性。不同水环境中,菌群α多样性、类群分析显示差异不显著;
  • 发育过程中对斑马鱼进行环境转换不影响肠道菌群的组成,而不同的发育阶段有较为明显的肠道菌群特异性;
  • 斑马鱼的发育阶段能够解释46.2%的肠道菌群多样性的差异,是肠道菌群多样性和演替的最重要因素。
主编推荐语
solo
生态演替是120年来生态学的中心主题。而对于水生动物来说,肠道菌群与环境的互作与陆地动物大相径庭。中山大学颜庆云、中科院水生生物研究所黄洁与研究团队,在NPJ Biofilms and Microbiomes发表文章,提出卵生鱼类发育对肠道菌群生态演替起决定性的作用而非环境因素的假说,并进行了验证。这一研究也在某种程度呼应了人类、小鼠中‘肠型’的说法。即肠道菌群‘成型’后,相对地理环境、性别、种族以及饮食等外界因素改变自身较为稳定。
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Host development overwhelms environmental dispersal in governing the ecological succession of zebrafish gut microbiota

在控制斑马鱼肠道菌群的生态演替方面宿主的发育压倒了环境扩散

10.1038/s41522-020-00176-2

01-19, Article

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Clarifying mechanisms underlying the ecological succession of gut microbiota is a central theme of gut ecology. Under experimental manipulations of zebrafish hatching and rearing environments, we test our core hypothesis that the host development will overwhelm environmental dispersal in governing fish gut microbial community succession due to host genetics, immunology, and gut nutrient niches. We find that zebrafish developmental stage substantially explains the gut microbial community succession, whereas the environmental effects do not significantly affect the gut microbiota succession from larvae to adult fish. The gut microbiotas of zebrafish are clearly separated according to fish developmental stages, and the degree of homogeneous selection governing gut microbiota succession is increasing with host development. This study advances our mechanistic understanding of the gut microbiota assembly and succession by integrating the host and environmental effects, which also provides new insights into the gut ecology of other aquatic animals.

First Authors:
Fanshu Xiao,Wengen Zhu

Correspondence Authors:
Jie Huang,Qingyun Yan

All Authors:
Fanshu Xiao,Wengen Zhu,Yuhe Yu,Zhili He,Bo Wu,Cheng Wang,Longfei Shu,Xinghao Li,Huaqun Yin,Jianjun Wang,Philippe Juneau,Xiafei Zheng,Yongjie Wu,Juan Li,Xiaojuan Chen,Dongwei Hou,Zhijian Huang,Jianguo He,Guohuan Xu,Liwei Xie,Jie Huang,Qingyun Yan

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