素食可能减少血液中的中性粒细胞、单核细胞和血小板
创作:王文东 审核:szx 2020年03月22日
  • 纳入53名健康的杂食者,26名接受全素饮食(VD),27名接受富含肉类的饮食(MD),干预4周,完成后进行1周混合饮食;
  • VD组的白细胞、中性粒细胞、单核细胞和血小板计数下降,且在干预4周后明显低于MD组;
  • 白细胞、中性粒细胞、单核细胞和血小板相互关联,与血清支链氨基酸水平一致,VD组的血清支链氨基酸水平明显低于MD组;
  • 免疫球蛋白唾液酸苷化、调节性T细胞百分比和IL-10水平在两组间无明显差别,且两组的BMI保持稳定。
主编推荐语
szx
Clinical Nutrition上发表的一项RCT研究结果,在4周的饮食干预中发现,严格素食可显著降低受试者血液中的中性粒细胞、单核细胞及血小板计数,但对淋巴细胞的数量及功能无显著影响。中性粒细胞、单核细胞及血小板计数与血清支链氨基酸及GM-CSF的水平相关,提示素食对上述细胞的影响可能通过mTOR信号通路。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片

Vegan diet reduces neutrophils, monocytes and platelets related to branched-chain amino acids – A randomized, controlled trial

全素饮食减少与支链氨基酸相关的中性粒细胞、单核细胞和血小板:一项RCT

10.1016/j.clnu.2020.02.011

2020-02-24, Article

Abstract & Authors:展开

Abstract:收起
Background: Vegan diet (VD) has improved inflammatory activity in patients with rheumatoid arthritis (RA) in several small controlled trials. The underlying mechanism remains widely unclear. We investigated the effect of a VD in comparison to a meat-rich diet (MD) on markers of inflammation (which have been shown to be relevant in patients with RA) in healthy volunteers.
Methods: 53 healthy, omnivore subjects were randomized to a controlled VD (n = 26) or MD (n = 27) for 4 weeks following a pre-treatment phase of a one week controlled mixed diet. Primary parameters of interest were sialylation of immunoglobulins, percentage of regulatory T-cells and level of interleukin 10 (IL10). Usual care immune parameters used in patients with RA and amino acid serum levels as well as granulocytes and monocytes colony stimulating factor (GM-CSF) serum levels were secondary parameters.
Results: In the VD group, total leukocyte, neutrophil, monocyte and platelet counts decreased and after four weeks they were significantly lower compared to the MD group (ANCOVA: leukocytes p = 0.003, neutrophils p = 0.001, monocytes p = 0.032, platelets p = 0.004). Leukocytes, neutrophils, monocytes, and platelets correlated with each other and likewise conform with serum levels of branched-chain amino acids, which were significantly lower in the VD compared to the MD group. The primary parameters did not differ between the groups and BMI remained stable in the two groups.
Conclusion: Four weeks of a controlled VD affected the number of neutrophils, monocytes and platelets but not the number or function of lymphocytes. The relation with branched-chain amino acids and GM-CSF suggests a mode of action via the mTOR signaling pathway.

First Authors:
Ann-Kathrin Lederer

Correspondence Authors:
Ann-Kathrin Lederer

All Authors:
Ann-Kathrin Lederer,Andrea Maul-Pavicic,Luciana Hannibal,Manuel Hettich,Carmen Steinborn,Carsten Gründemann,Amy Marisa Zimmermann-Klemd,Alexander Müller,Bettina Sehnert,Ulrich Salzer,Reinhild Klein,Reinhard E Voll,Yvonne Samstag,Roman Huber

评论