秦楠+朱听:城市空气颗粒物中的菌群
  • 对北京2012-2013年间(6个月中)106个空气PM2.5和PM10样本进行纵向宏基因组测序,发现两样本间的菌群组成和功能无差异,但都随时间发生变化;
  • 菌群以痤疮丙酸杆菌、大肠杆菌、鲁氏不动杆菌、淀粉乳杆菌和罗伊氏乳杆菌为主,以及几种病毒;
  • 抗生素耐药性和解毒基因广泛存在;
  • 随污染物浓度增加,两样本中与人、狗和猪粪便相关的微生物显著增加,且PM10中更为明显;
  • 空气菌群多样性与土地和会环境相当,且这些菌群可能与生命健康相关。
主编推荐语
兵兵
上海第十人民医院秦楠和清华大学朱听与团队,近期在Genome Biology发表研究,对2012-2013年间北京的空气样本,进行宏基因组测序分析,测定了空气中含有的主要菌群,并发现菌群的抗生素耐受性普遍存在。随着雾霾的加重,空气菌群组成呈动态变化,且来源于哺乳动物的菌群增加。该研究为雾霾天气的致病性提供了证据。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Genome Biology [IF:10.806]

Longitudinal survey of microbiome associated with particulate matter in a megacity

大都市中与颗粒物相关的微生物群落的纵向调查

10.1186/s13059-020-01964-x

2020-03-03, Article

Abstract & Authors:展开

Abstract:收起
Background: While the physical and chemical properties of airborne particulate matter (PM) have been extensively studied, their associated microbiome remains largely unexplored. Here, we performed a longitudinal metagenomic survey of 106 samples of airborne PM2.5 and PM10 in Beijing over a period of 6 months in 2012 and 2013, including those from several historically severe smog events.
Results: We observed that the microbiome composition and functional potential were conserved between PM2.5 and PM10, although considerable temporal variations existed. Among the airborne microorganisms, Propionibacterium acnes, Escherichia coli, Acinetobacter lwoffii, Lactobacillus amylovorus, and Lactobacillus reuteri dominated, along with several viral species. We further identified an extensive repertoire of genes involved in antibiotic resistance and detoxification, including transporters, transpeptidases, and thioredoxins. Sample stratification based on Air Quality Index (AQI) demonstrated that many microbial species, including those associated with human, dog, and mouse feces, exhibit AQI-dependent incidence dynamics. The phylogenetic and functional diversity of air microbiome is comparable to those of soil and water environments, as its composition likely derives from a wide variety of sources.
Conclusions: Airborne particulate matter accommodates rich and dynamic microbial communities, including a range of microbial elements that are associated with potential health consequences.

First Authors:
Nan Qin,Peng Liang,Chunyan Wu

Correspondence Authors:
Nan Qin,Jack A Gilbert,Ting F Zhu

All Authors:
Nan Qin,Peng Liang,Chunyan Wu,Guanqun Wang,Qian Xu,Xiao Xiong,Tingting Wang,Moreno Zolfo,Nicola Segata,Huanlong Qin,Rob Knight,Jack A Gilbert,Ting F Zhu

图片
锐翌基因微信公众号

空气微小颗粒可附着微生物,或可传播人类致病菌

WP,2020-03-09

图片
BMC科研永不止步微信公众号

北京空气颗粒物相关微生物群落的纵向调查 | Genome Biology

BMC 中国,2020-03-06

评论