Cell子刊:你的胆固醇水平或由肠道细菌来决定
  • 对宏基因组、代谢组、分离基因组和酶功能的综合分析,鉴定出在人类肠道微生物组中参与胆固醇代谢的候选细菌基因ismA,编码有助于粪醇形成的微生物胆固醇脱氢酶;
  • ismA存在于一个未培养的细菌分支中,属于梭菌类群IV,且普遍存在于不同地理分布的人群中;
  • IsmA编码细菌的存在与人体的粪便胆固醇降低、粪便胆石酮和粪醇水平升高有关;
  • 含有形成粪醇细菌的个体,其血清总胆固醇水平显著降低,效果与脂质稳态基因的变化相当。
主编推荐语
爱的抉择
人类肠道微生物具有强大的代谢能力,但肠道微生物与人类代谢之间互作的机制仍不清楚。《Cell Host and Microbe》近期发表文章,鉴定出肠道细菌的胆固醇脱氢酶,并揭示出胆固醇代谢细菌的出现与宿主的粪便、血清总胆固醇降低相关,可直接影响人类健康。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片

Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level

未培养的人类肠道细菌的胆固醇代谢影响宿主的胆固醇水平

10.1016/j.chom.2020.05.013

06-15, Article

Abstract & Authors:展开

Abstract:收起
The human microbiome encodes extensive metabolic capabilities, but our understanding of the mechanisms linking gut microbes to human metabolism remains limited. Here, we focus on the conversion of cholesterol to the poorly absorbed sterol coprostanol by the gut microbiota to develop a framework for the identification of functional enzymes and microbes. By integrating paired metagenomics and metabolomics data from existing cohorts with biochemical knowledge and experimentation, we predict and validate a group of microbial cholesterol dehydrogenases that contribute to coprostanol formation. These enzymes are encoded by ismA genes in a clade of uncultured microorganisms, which are prevalent in geographically diverse human cohorts. Individuals harboring coprostanol-forming microbes have significantly lower fecal cholesterol levels and lower serum total cholesterol with effects comparable to those attributed to variations in lipid homeostasis genes. Thus, cholesterol metabolism by these microbes may play important roles in reducing intestinal and serum cholesterol concentrations, directly impacting human health.

First Authors:
Douglas J Kenny,Damian R Plichta

Correspondence Authors:
Emily P Balskus,Ramnik J Xavier

All Authors:
Douglas J Kenny,Damian R Plichta,Dmitry Shungin,Nitzan Koppel,A Brantley Hall,Beverly Fu,Ramachandran S Vasan,Stanley Y Shaw,Hera Vlamakis,Emily P Balskus,Ramnik J Xavier

图片
Nature Reviews Microbiology期刊

Reducing cholesterol levels

2020-06-22

图片
ScienceDaily新闻网站

Microbes might manage your cholesterol

2020-06-17

评论