结直肠癌患者日渐年轻化
创作:Lexi 审核:Lexi 2019年08月05日
  • 分析美国国家癌症数据库2004-2015年结直肠癌(CRC)患者数据,共130,165位50岁以下(年轻)和1,055,598位50岁以上患者;
  • 在所有CRC患者中,年轻患者比例增加,2015年占比12.2%,2004年占比10.0%;
  • 年轻成年患者疾病进展分期更靠后,III/IV期患者中年轻患者占比51.6%;
  • 年轻男性患者中,只有非西班牙裔白人患者数量增加,年轻女性患者中,西班牙裔和非西班牙裔白人患者数量都增加;
  • 更高收入年轻患者比例增加更多,且城市患者比例增加。
主编推荐语
Lexi
各类数据显示,最近数十年美国50岁以下人群结直肠癌发病率有所增加,这意味着国家癌症指南建议的结直肠癌起始筛查年龄应有所修改。该回顾性研究分析了美国国家癌症数据库2004-2015年结直肠癌(CRC)患者数据,结果显示50岁以下患者比例确有增加,且更年轻的患者疾病进展分期更靠后。该研究报告可为结直肠癌筛查指南提供修改依据。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Cancer [IF:5.742]

Recent trends in the age at diagnosis of colorectal cancer in the US National Cancer Data Base, 2004-2015

美国国家癌症数据库中结直肠癌确诊年龄新趋势(2004-2015年)

10.1002/cncr.32347

2019-07-22, Article

Abstract & Authors:展开

Abstract:收起
BACKGROUND: The incidence of colorectal cancer (CRC) in adults younger than 50 years has increased in the United States over the past decades according to Surveillance, Epidemiology, and End Results data. National guidelines conflict over beginning screening at the age of 45 or 50 years.
METHODS: This was a retrospective study of National Cancer Data Base data from 2004 to 2015. The Cochran-Armitage test for trend was used to assess changes in the proportion of cases diagnosed at an age younger than 50 years.
RESULTS: This study identified 130,165 patients diagnosed at an age younger than 50 years and 1,055,598 patients diagnosed at the age of 50 years or older. The proportion of the total number of patients diagnosed with CRC at an age younger than 50 years rose (12.2% in 2015 vs 10.0% in 2004; P < .0001). Younger adults presented with more advanced disease (stage III/IV; 51.6% vs 40.0% of those 50 years old or older). Among men, diagnosis at ages younger than 50 years rose only in non-Hispanic whites (P < .0001), whereas among women, Hispanic and non-Hispanic whites had increases in younger diagnoses over time (P < .05). All income quartiles had a proportional increase in younger adults over time (P < .001), with the highest income quartile having the highest proportion of younger cases. The proportion of younger onset CRC cases rose in urban areas (P < .001) but did not rise in rural areas.
CONCLUSIONS: The proportion of persons diagnosed with CRC at an age younger than 50 years in the United States has continued to increase over the past decade, and younger adults present with more advanced disease. These data should be considered in the ongoing discussion of screening guidelines.

First Authors:
John Virostko

Correspondence Authors:
Boone Goodgame

All Authors:
John Virostko,Anna Capasso,Thomas E Yankeelov,Boone Goodgame

评论