• 关于肠道菌群(失调)与免疫系统的纲领性文献:
  • 肠道菌群失调与众多疾病有关,但阐述其间的机制以及因果性的宿主-菌群关联都还不算明确;
  • 本文探讨微生态失调的概念以及它们与免疫学的关联、细菌失调的原因与后果以及它们在常见疾病分子病因学中的作用、对合理设计新疗法的影响;
  • 对生态失调缘起、它的内生和外在调节进程、其对下游通路影响的分子水平理解,有助于开发靶向微生物组以应对许多常见自身免疫性疾病的疗法。

Dysbiosis and the immune system



2017-03-06, Review

Abstract & Authors:展开

Throughout the past century, we have seen the emergence of a large number of multifactorial diseases, including inflammatory, autoimmune, metabolic, neoplastic and neurodegenerative diseases, many of which have been recently associated with intestinal dysbiosis - that is, compositional and functional alterations of the gut microbiome. In linking the pathogenesis of common diseases to dysbiosis, the microbiome field is challenged to decipher the mechanisms involved in the de novo generation and the persistence of dysbiotic microbiome configurations, and to differentiate causal host-microbiome associations from secondary microbial changes that accompany disease course. In this Review, we categorize dysbiosis in conceptual terms and provide an overview of immunological associations; the causes and consequences of bacterial dysbiosis, and their involvement in the molecular aetiology of common diseases; and implications for the rational design of new therapeutic approaches. A molecular- level understanding of the origins of dysbiosis, its endogenous and environmental regulatory processes, and its downstream effects may enable us to develop microbiome-targeting therapies for a multitude of common immune-mediated diseases.

First Authors:
Maayan Levy

Correspondence Authors:
Eran Elinav

All Authors:
Maayan Levy,Aleksandra A Kolodziejczyk,Christoph A Thaiss,Eran Elinav