孕期接触空气污染,宝宝自闭症风险微弱增高
创作:Epi汪 审核:Epi汪 2019年11月01日
  • 检索公开发表的文献数据库,最终纳入25篇研究,采用频率模型和贝叶斯模型分别分析母亲孕期空气污染暴露于后代自闭症谱系障碍(ASD)的关联;
  • 总体上看,孕期暴露PM2.5和NO2其后代发生ASD的风险分别提高1.06、1.02倍;
  • 而孕期PM10和臭氧的暴露与后代ASD的关联更加微弱;
  • 孕晚期空气污染物的暴露与后代ASD的关联强度更大,但不同研究间关于不同暴露时期的风险结果不一致;
  • 母亲孕期空气污染暴露与后代ASD的关联有待进一步的研究。
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本研究综合了关于孕期空气污染与后代自闭症风险的相关文章,发现PM2.5的关联较强,而NO2的证据较弱。本研究为进一步探索相关主题提供新的思路。
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Maternal exposure to air pollution and risk of autism in children: A systematic review and meta-analysis

母亲暴露于空气污染和儿童自闭症风险的关系:一项系统综述和荟萃分析

10.1016/j.envpol.2019.113307

2019-09-26, Article

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Background: The number of children diagnosed with autism spectrum disorder (ASD) has been increasing. Previous studies suggested potential association between pregnancy air pollution exposure and ASD. This systematic review and meta-analysis is intended to summarize the association between maternal exposure to outdoor air pollution and ASD in children by trimester based on recent studies.
Methods: A systematic literature search in 3 databases (Medline, Embase, and Web of Science) was performed using subject headings related to ASD and air pollution since 2007. Eligible studies were screened and evaluated based on predetermined criteria. For meta-analyses, the studies were grouped by air pollutant and exposure time (prenatal period and trimesters). Within-group studies were standardized by log odds ratio (OR) and then combined by three meta-analysis methods: frequentist fixed and random effects models, and Bayesian random effects model.
Results: Initial search identified 1,564 papers, of which 25 studies remained for final analysis after duplicates and ineligible studies were removed. Of the 25 studies, 13, 14, 12, and 7 studies investigated ASD in children associated with PM2.5, PM10, NO2, and ozone, respectively. The frequentist and Bayesian random effects models resulted in different statistical significance. For prenatal period, frequentist meta-analysis returned significant pooled ORs with 95% confidence intervals, 1.06(1.01,1.11) for PM2.5 and 1.02(1.01,1.04) for NO2, whereas Bayesian meta-analysis showed similar ORs with wider 95% posterior intervals, 1.06(1.00,1.13) for PM2.5 and 1.02(1.00,1.05) for NO2. Third trimester appeared to have higher pooled ORs for PM2.5, PM10, and ozone, but patterns in the time-varying associations over the trimester were inconsistent.
Conclusions: For positive association between maternal exposure to ambient air pollution and ASD in children, there is some evidence for PM2.5, weak evidence for NO2 and little evidence for PM10 and ozone. However, patterns in associations over trimesters were inconsistent among studies and among air pollutants.

First Authors:
HeeKyoung Chun

Correspondence Authors:
Hwashin H Shin

All Authors:
HeeKyoung Chun,Cheryl Leung,Shi Wu Wen,Judy McDonald,Hwashin H Shin

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