母亲酒精滥用,儿童负性生活事件风险高
创作:Epi汪 审核:Epi汪 2020年03月06日
  • 对澳大利亚多个数据库进行联合,纳入2万余名有酒精使用障碍(医疗系统中被诊断为酒精滥用相关的精神和行为问题)的女性,及6万余名对照组女性数据;
  • 其儿童发展的负性事件包括不良妊娠结局(低于胎龄儿、早产、出生缺陷、智力障碍、脑瘫)、学习成绩差、有犯罪记录、受虐待经历等;
  • 暴露组儿童负性事件的发生率是对照组的2.67倍;
  • 如果母亲在妊娠期被确诊,则儿童负性事件发生率将增高至4~5倍;
  • 本地居民和非本地居民的影响并不一致。
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Epi汪
本研究将一系列儿童可能面临的生理、心理问题归纳为负性生活事件,并发现母亲有“酗酒”病史的,其面临负性生活事件的风险更高。该研究对酒精滥用问题的管控,具有重大的指导意义。
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Pediatrics [IF:7.124]

Maternal Alcohol-Use Disorder and Child Outcomes

母亲酒精使用障碍和儿童结局的关联

10.1542/peds.2019-1574

2020-02-24, Article

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Abstract:收起
OBJECTIVES: Investigate the relationship between maternal alcohol-use disorder and multiple biological and social child outcomes, including birth outcomes, child protection, justice contact, and academic outcomes for both Indigenous and non-Indigenous children.
METHODS: Women with a birth recorded on the Western Australian Midwives Notification System (1983–2007) and their offspring were in scope. The exposed cohort were mothers with an alcohol-related diagnosis (International Classification of Diseases, Ninth Revision and International Classification of Diseases, 10th Revision) recorded in an administrative data set and their offspring (non-Indigenous: n = 13 969; Indigenous: n = 9635). The exposed cohort was frequency matched with mothers with no record of an alcohol-related diagnosis and their offspring (comparison cohort; non-Indigenous: n = 40 302; Indigenous: n = 20 533).
RESULTS: Over half of exposed non-Indigenous children (55%) and 84% of exposed Indigenous children experienced ≥1 negative outcome. The likelihood of any negative outcome was significantly higher for the exposed than the comparison cohort (non-Indigenous: odds ratio [OR] = 2.67 [95% confidence interval (CI) = 2.56–2.78]; Indigenous: OR = 2.67 [95% CI = 2.50–2.85]). The odds were greatest for children whose mothers received a diagnosis during pregnancy (non-Indigenous: OR = 4.65 [95% CI = 3.87–5.59]; Indigenous: OR = 5.18 [95% CI = 4.10–6.55]); however, numbers were small.
CONCLUSIONS: The effects of maternal alcohol-use disorder are experienced by the majority of exposed children rather than a vulnerable subgroup of this population. These findings highlight the need for universal prevention strategies to reduce harmful alcohol use and targeted interventions to support at-risk women and children.

First Authors:
Colleen O'Leary

Correspondence Authors:
Colleen O'Leary

All Authors:
Colleen O'Leary,David Lawrence,Katherine Hafekost,Stephen R Zubrick,Carol Bower

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