大连医科大学李华军:岩藻多糖和低聚半乳糖改善大鼠血脂异常
创作:迟卉 审核:aluba 2019年05月11日
  • 正常饮食/高脂饮食喂养大鼠分别强饲生理盐水/岩藻多糖(FUC)/低聚半乳糖(GOS)/FUC+GOS,干预持续8周;
  • 补充GOS和FUC改善了大鼠高脂饮食诱导的血清胆固醇、LDL-C、LPS及总胆汁酸异常;
  • 并缓解了肝组织脂肪变性和主动脉弓损伤,增加了小肠中的胆固醇7-α羟化酶表达和胆盐水解酶(BSH)活性;
  • 同时,GOS和FUC对肠道菌群的组成也有改善作用;
  • 在体外,补充GOS和FUC增加了干酪乳杆菌DM8121的BSH活性。
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来自大连医科大学李华军团队在《Nutrition》上发表的一项最新研究,发现两种益生元——岩藻多糖和低聚半乳糖在体外可增加益生菌——干酪乳杆菌DM8121的胆盐水解酶活性,在体内可改善高脂饮食诱导的大鼠血脂异常及其它相关症状。
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Nutrition [IF:3.639]

Fucoidan and galactooligosaccharides ameliorate high-fat diet–induced dyslipidemia in rats by modulating the gut microbiota and bile acid metabolism

岩藻多糖和低聚半乳糖通过调节肠道菌群和胆汁酸代谢改善高脂饮食诱导的大鼠血脂异常

10.1016/j.nut.2019.03.001

2019-03-11, Article

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Objectives: Dyslipidemia is an important risk factor for cardiovascular diseases. Fucoidan (FUC) is a polysaccharide extracted from brown marine algae with various biological activities. Galactooligosaccharides (GOS) are important prebiotics that exert benefits on the intestinal microbiota. The aim of this study was to investigate the effects of FUC and GOS on dyslipidemia in rats by modulating the gut microbiota and bile acid metabolism.
Methods: Twenty-four male inbred Sprague-Dawley (SD) rats aged 8 wk were fed a normal or high-fat diet (HFD) for 8 wk. During the feeding period, rats were gavaged with normal saline solution, FUC solution (100 mg/kg),or GOS solution (800 mg/kg), or a combination of both once daily. Serum biochemical parameters were determined, and the gut microbiota were analyzed via 16S rRNA gene sequencing. Bile salt hydrolase (BSH) activity in the small intestinal contents was also analyzed. The effects of FUC and GOS on Lactobacillus casei DM8121 were analyzed in vitro.
Results: In rats, GOS and FUC supplementation significantly improved serum total cholesterol, low-density lipoprotein cholesterol, lipopolysaccharide, serum total bile acid, hepatic tissue steatosis, aortic arch injury, gut microbiota, serum high-density lipoprotein cholesterol, cholesterol 7-alpha hydroxylase expression in the liver, and BSH activity in the small intestinal contents. In an in vitro experiment, GOS and FUC supplementation significantly increased L. casei DM8121’s BSH activity.
Conclusions: In rats, FUC and GOS supplementation improved serum dyslipidemia, gut microbiota, BSH activity, and bile acid metabolism–related pathways. In vitro, GOS and FUC supplementation increased L. casei DM8121’s BSH activity.

First Authors:
Qichao Chen,Min Liu

Correspondence Authors:
Huajun Li

All Authors:
Qichao Chen,Min Liu,Pengyu Zhang,Shujun Fan,Jinli Huang,Shunying Yu,Caihua Zhang,Huajun Li

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