Cell子刊:皮肤共生真菌如何促进特应性皮炎
创作:szx 审核:szx 2019年03月23日
  • 马拉色菌属等哺乳动物皮肤上的共生真菌与特应性皮炎相关;
  • 马拉色菌属物种可选择性诱导IL-17及相关细胞因子的产生,这一过程对抑制真菌过度生长起到关键作用;
  • 破坏IL-23-IL-17信号轴,可抑制马拉色菌属特应性皮炎免疫反应;
  • 在皮肤完整性受损的情况下(模拟特异性皮炎),马拉色菌属恶化皮肤炎症,该过程依赖于IL-23及IL-17;
  • 马拉色菌属特异性的CCR6+ 记忆性Th17细胞在健康人及特应性皮炎患者中均存在,但在患者中比例较高。
主编推荐语
szx
《Cell Host and Microbe》上发表的一项最新研究,发现哺乳动物皮肤上以马拉色菌属为代表的共生真菌可触发皮肤的Th17免疫应答,这种应答既可抑制真菌的过度生长,又可能促进特应性皮炎的发生发展。该结果对研究真菌-免疫互作以及特应性皮炎病理具有重要参考价值。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片

The Skin Commensal Yeast Malassezia Triggers a Type 17 Response that Coordinates Anti-fungal Immunity and Exacerbates Skin Inflammation

皮肤共生真菌马拉色菌触发Th17应答以调节抗真菌免疫病恶化皮肤炎症

10.1016/j.chom.2019.02.002

2019-03-13, Article

Abstract & Authors:展开

Abstract:收起
Commensal fungi of the mammalian skin, such as those of the genus Malassezia, are associated with atopic dermatitis and other common inflammatory skin disorders. Understanding of the causative relationship between fungal commensalism and disease manifestation remains incomplete. By developing a murine epicutaneous infection model, we found Malassezia spp. selectively induce IL-17 and related cytokines. This response is key in preventing fungal overgrowth on the skin, as disruption of the IL-23-IL-17 axis compromises Malassezia-specific cutaneous immunity. Under conditions of impaired skin integrity, mimicking a hallmark of atopic dermatitis, the presence of Malassezia dramatically aggravates cutaneous inflammation, which again was IL-23 and IL-17 dependent. Consistently, we found a CCR6 Th17 subset of memory T cells to be Malassezia specific in both healthy individuals and atopic dermatitis patients, whereby the latter showed enhanced frequency of these cells. Thus, the Malassezia-induced type 17 response is pivotal in orchestrating antifungal immunity and in actively promoting skin inflammation.

First Authors:
Florian Sparber

Correspondence Authors:
Salomé LeibundGut-Landmann

All Authors:
Florian Sparber,Corinne De Gregorio,Simone Steckholzer,Filipa M Ferreira,Tamas Dolowschiak,Fiorella Ruchti,Florian R Kirchner,Sarah Mertens,Immo Prinz,Nicole Joller,Thorsten Buch,Martin Glatz,Federica Sallusto,Salomé LeibundGut-Landmann

评论