抗生素对人体肠道菌群的长期影响
  • 纳入1413人(女性57.5%,中位年龄62.6岁),研究不同抗菌药物对肠道菌群的长期影响;
  • 在大环内酯类和林可酰胺类药物使用后的4年内,及β-内酰胺类药物使用后的第1年内,肠道微生物组α多样性显着降低;
  • 不同抗生素对肠道菌群β多样性影响的持续时间不同(大环内酯类和林可酰胺类长达4年,β-内酰胺类在第1年,喹诺酮类至少1年);
  • 抗厌氧菌活性高的药物在治疗后1年内会增加厚壁菌门细菌占比,而其它抗菌药物则增加拟杆菌门比例。
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mildbreeze
抗生素能对肠道菌群造成很大的影响,但其对人体肠道菌群的长期作用尚需更多数据。Gut Microbes近期发表的一项研究,揭示了不同种类的抗生素对中老年人肠道菌群的长期影响。
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Gut Microbes [IF:7.74]

Long-term effects of antimicrobial drugs on the composition of the human gut microbiota

抗生素药物对人体肠道菌群组成的长期影响

10.1080/19490976.2020.1791677

2020-09-29, Article

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Introduction: Antimicrobial drugs are known to have effects on the human gut microbiota. We studied the long-term temporal relationship between several antimicrobial drug groups and the composition of the human gut microbiota determined in feces samples.
Methods: Feces samples were obtained from a community-dwelling cohort of middle-aged and elderly individuals (Rotterdam Study). Bacterial DNA was isolated and sequenced using V3/V4 16 S ribosomal RNA sequencing (Illumina MiSeq). The time between the last prescription of several antimicrobial drug groups and the day of sampling was categorized into 0–12, 12–24, 24–48 and >48 months. The effects of the antimicrobial drug groups on the Shannon alpha-diversity (diversity), the Bray–Curtis beta-diversity (community structure), the Firmicutes/Bacteroidetes (F/B) ratio and individual genera were determined.
Results: We studied the gut microbiota of 1413 individuals (57.5% female, median age 62.6 years). The alpha-diversity was significantly lower up to 4 years after prescriptions of macrolides and lincosamides. It was also lower in the first year after the use of beta-lactams. The community structure (beta-diversity) of the microbiota was significantly different up to 4 years for macrolides and lincosamides, the first year for beta-lactams and at least the first year for quinolones. For the F/B ratio, drugs with a high anaerobic activity shifted the ratio toward Firmicutes in the first year whereas other antimicrobial drugs shifted the ratio toward Bacteroidetes.
Conclusion: Use of antimicrobial drugs is associated with a shift in the composition of the gut microbiota.These effects differ in strength and duration, depending on the antimicrobial drug group used. These findings should be considered when prescribing antimicrobial drugs.

First Authors:
M Mulder

Correspondence Authors:
B H Stricker

All Authors:
M Mulder,D Radjabzadeh,J C Kiefte-de Jong,A G Uitterlinden,R Kraaij,B H Stricker,A Verbon

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