中科院南海海洋研究所:牡蛎多糖调节肠道菌群改善黏膜炎
创作:兵兵 审核:兵兵 01月31日
  • 牡蛎多糖(CHP)可以增加绒毛高度、 隐窝深度、粘膜厚度、绒毛表面积以及绒毛/隐窝比;
  • 同时,CHP还可以降低炎症因子IL-1β、 IL-6以及TNF-α,恢复TP、 ALB、PA、 TRF、 IgA、IgM和IgG水平;
  • CHP促进产丙、丁酸菌增殖,降低拟杆菌属、普雷沃氏菌(UCG-001 )以及理研菌(RC9_gut_group)丰度,进而干预TLRs信号通路,上述因子改变与此相关;
  • CHP可以通过调节肠道菌群改善5-氟尿嘧啶诱导的S180肿瘤携带小鼠的肠膜炎和营养不良。
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兵兵
中科院南海海洋研究所万鹏团队研究成果。研究首先从 C. hongkongensis中提取获得CHP,并进行了结构的鉴定。建立S180肿瘤携带小鼠模型,利用CHP(150 mg/kg)进行干预。研究结果显示,CHP明显改善患病小鼠肠道生理状态,平衡相关代谢因子。在此过程中,小鼠的肠道菌群发生显著变化。CHP对患病小鼠的改善作用与肠道菌群有关。
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Oyster polysaccharides ameliorate intestinal mucositis and improve metabolism in 5-fluorouracil-treated S180 tumour-bearing mice

牡蛎多糖缓解5-氟尿嘧啶诱导的S180肿瘤携带小鼠的小肠粘膜炎并改善其代谢

10.1016/j.carbpol.2020.117545

2020-12-20, Article

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The purpose of this study was to investigated the potential role of gut microbiota in protecting the intestinal barrier and improving nutritional metabolism in 5-FU-treated S180 tumour-bearing mice after treatment with oyster polysaccharide (CHP). CHP, with an α-(1→4) d-linked glucose backbone and (→4,6)-α-d-Glc-(1→) branches every 4.7 residues on average, increased the villus height, crypt depth, mucosa thickness, villus surface area and V/C ratio; decreased the expression of IL-1β, IL-6, and TNF-α; and even restored the TP, ALB, PA, TRF, IgA, IgM and IgG levels to normal levels. All these factors are related to CHP increasing the propionic acid- and butyric acid-producing microorganisms and decreasing the production of Bacteroides, Prevotellaceae_UCG-001 and Rikenellaceae_RC9_gut_group, thus affecting the TLRs signalling pathway. In conclusion, CHP attenuates 5-FU-induced intestinal mucositis and malnutrition by regulating gut microbiota, and can improve the prognosis of patients receiving chemotherapy.

First Authors:
Bingna Cai

Correspondence Authors:
Peng Wan

All Authors:
Bingna Cai,Jianyu Pan,Hua Chen,Xin Chen,Ziqing Ye,Huabiao Yuan,Huili Sun,Peng Wan

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