孕期环境污染物暴露或影响孕期增重
  • 纳入1213名孕妇,分别在孕早期和孕中期检测尿样中双酚类和邻苯二甲酸盐类物质浓度,并随访孕期增重情况;
  • 总体来看,尿液中总双酚类物质及双酚S浓度增加,孕期增重量降低,但仍然在正常增重参考范围内;
  • 从孕期上看,孕早期双酚A浓度增加与孕中晚期增重减少存在相关;
  • 但孕中期这些物质浓度增加与孕期增重无关;
  • 双酚类物质暴露可能会扰乱激素通路,从而影响妊娠期体重增加,但并无直接证据表明其会导致妊娠期增重不足。
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该队列样本研究结果提示,孕早期双酚类物质暴露与孕中晚期增重的降低有关。但是这种增重的降低程度并没有达到“增重不足”或者影响胎儿发育的程度。孕期环境激素暴露的影响有待进一步的研究。
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Maternal bisphenol and phthalate urine concentrations and weight gain during pregnancy

母亲在妊娠期间尿液中双酚类和邻苯二甲酸盐浓度与孕期增重的关联

10.1016/j.envint.2019.105342

2019-12-18, Article

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Background: Insufficient or excessive gestational weight gain are associated with increased risks of adverse birth and childhood outcomes. Increasing evidence suggests that exposure to bisphenols and phthalates may disrupt hormonal pathways and thereby influence gestational weight gain.
Objective: To examine the associations of early and mid-pregnancy bisphenol and phthalate urine concentrations with gestational weight gain.
Methods: In a population-based prospective cohort study among 1,213 pregnant women, we measured early and mid-pregnancy bisphenol and phthalate urine concentrations. Maternal anthropometrics before pregnancy were obtained by questionnaire and repeatedly measured at our research center during pregnancy. We used linear and logistic regressions to evaluate the associations of bisphenols and phthalates with total and period-specific gestational weight gain.
Results: Higher maternal total bisphenols and bisphenol S were associated with a lower total gestational weight gain at nominal level. Stratification by body mass index group showed that higher total bisphenols and bisphenol S were associated with lower total gestational weight gain specifically in normal weight women (respectively −509 g [95% CI −819, −198] and −398 g [95% CI −627, −169]). Each log unit increase in early pregnancy total bisphenol and bisphenol A urine concentrations were associated with lower mid- to late pregnancy gestational weight gain in the whole group (effect estimates −218 g/log unit increase [95% CI −334, −102] and −132 g/log unit increase [95% CI −231, −34], respectively). These associations were independent of mid-pregnancy compounds. Mid-pregnancy bisphenols and phthalates concentrations were not associated with gestational weight gain.
Discussion: Higher maternal bisphenol urine concentrations in early pregnancy may lead to reduced gestational weight in second half of pregnancy. Further research is needed to assess the effects of maternal bisphenols and phthalates urine concentrations on placental and fetal growth and development.

First Authors:
Elise M Philips

Correspondence Authors:
Vincent W V Jaddoe

All Authors:
Elise M Philips,Susana Santos,Eric A P Steegers,Alexandros G Asimakopoulos,Kurunthachalam Kannan,Leonardo Trasande,Vincent W V Jaddoe

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