张和平团队:益生菌增强肠道菌群的神经刺激活性以缓解压力与焦虑
创作:菌菌君 审核:szx 01月27日
  • 受试者口服植物乳杆菌P-8(n=43)或安慰剂(n=36)12周;
  • 干预后,安慰剂组的粪便菌群多样性降低,而益生菌组无显著变化,且安慰剂组粪便菌群的Aitchison距离变化显著高于益生菌组;
  • 益生菌组的粪便菌群中青春双歧杆菌、长双歧杆菌和柔嫩梭菌显著增加,而粪便罗斯氏菌等显著减少;
  • 益生菌可富集神经递质合成/消耗相关通路,以及某些预测的神经活性菌群代谢产物(如短链脂肪酸、γ-氨基丁酸、花生四烯酸和神经磷脂)。
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先前的一项随机双盲安慰剂对照试验表明,补充植物乳杆菌P-8可缓解成年人的压力与焦虑。内蒙古农业大学的张和平团队在Neurobiology of Stress上发表的一项最新研究,对该试验的结果进行深入分析后发现,植物乳杆菌P-8可调节肠道菌群多样性及组成,增加肠道菌群中的神经递质合成/消耗相关通路,并富集潜在的神经活性菌群代谢产物。
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Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota

摄入益生菌可通过调节肠道菌群的潜在神经刺激作用来缓解人的压力和焦虑症状

10.1016/j.ynstr.2021.100294

01-12, Article

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Stress has been shown to disturb the balance of human intestinal microbiota and subsequently causes mental health problems like anxiety and depression. Our previous study showed that ingesting the probiotic strain, Lactobacillus (L.) plantarum P-8, for 12 weeks could alleviate stress and anxiety of stressed adults. The current study was a follow-up work aiming to investigate the functional role of the gut metagenomes in the observed beneficial effects. The fecal metagenomes of the probiotic (n = 43) and placebo (n = 36) receivers were analyzed in depth. The gut microbiomes of the placebo group at weeks 0 and 12 showed a significantly greater Aitchison distance (P < 0.001) compared with the probiotic group. Meanwhile, the Shannon diversity index of the placebo group (P < 0.05) but not the probiotic group decreased significantly at week 12. Additionally, significantly more species-level genome bins (SGBs) of Bifidobacterium adolescentis, Bifidobacterium longum, and Fecalibacterium prausnitzii (P < 0.01) were identified in the fecal metagenomes of the probiotic group, while the abundances of SGBs representing the species Roseburia faecis and Fusicatenibacter saccharivorans decreased significantly (P < 0.05). Furthermore, the 12-week probiotic supplementation enhanced the diversity of neurotransmitter-synthesizing/consuming SGBs and the levels of some predicted microbial neuroactive metabolites (e.g., short-chain fatty acids, gamma-aminobutyric acid, arachidonic acid, and sphingomyelin). Our results showed a potential link between probiotic-induced gut microbiota modulation and stress/anxiety alleviation in stressed adults, supporting that the gut-brain axis was involved in relieving stress-related symptoms. The beneficial effect relied not only on microbial diversity changes but more importantly gut metagenome modulations at the SGB and functional gene levels.

First Authors:
Teng Ma,Hao Jin

Correspondence Authors:
Heping Zhang

All Authors:
Teng Ma,Hao Jin,Lai-Yu Kwok,Zhihong Sun,Min-Tze Liong,Heping Zhang

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