食用纤维预防乳腺癌?(综述)
创作:Lexi 审核:Lexi 2020年04月12日
  • 为探讨纤维摄入总量和类型与乳腺癌发病的关系,分析了21篇前瞻性研究报告;
  • 绝经前或绝经后,较高的总纤维摄入量均与较低的乳腺癌风险相关;
  • 可溶性纤维与乳腺癌风险显著负相关,不溶性纤维或与乳腺癌风险负相关;
  • 总纤维摄入量与雌激素、黄体酮受体双阳性或双阴性乳腺癌风险之间无显著负相关;
  • 未发现区域、随访时间、酒精摄入、吸烟、良性乳腺病史或乳腺癌家族史等作为研究中总纤维摄入与整体乳腺癌风险相关性的异质性来源。
主编推荐语
Lexi
纤维摄入量与乳腺癌风险之间的关系需要更多证据支持,最新发表在Cancer的系统性回顾和前瞻性荟萃分析探讨了纤维摄入总量和类型与乳腺癌发病的关系。该荟萃分析发现较高的总纤维摄入量均与较低的乳腺癌风险相关,该相关性与绝经与否无关。可溶性纤维与乳腺癌风险呈显著负相关。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Cancer [IF:5.742]

Fiber consumption and breast cancer incidence: A systematic review and meta‐analysis of prospective studies

纤维摄入和乳腺癌发病率:系统性回顾和前瞻性研究的荟萃分析

10.1002/cncr.32816

2020-04-06, Article

Abstract & Authors:展开

Abstract:收起
Background: Associations between fiber intake and breast cancer risk have been evaluated in prospective studies, but overall, the evidence is inconsistent. The authors performed a systematic review and meta‐analysis of prospective studies to investigate the relation between intake of total and types of fiber with breast cancer incidence.
Methods: The MEDLINE and Excerpta Medica dataBASE (EMBASE) databases were searched through July 2019 for prospective studies that reported on the association between fiber consumption and incident breast cancer. The pooled relative risk (RR) and 95% confidence intervals (95% CI) were estimated comparing the highest versus the lowest category of total and types of fiber consumption, using a random‐effects meta‐analysis.
Results: The authors identified 17 cohort trials, 2 nested case‐control trials, and 1 clinical trial. Total fiber consumption was associated with an 8% lower risk of breast cancer (comparing the highest versus the lowest category, pooled RR, 0.92; 95% CI, 0.88‐0.95 [I2 = 12.6%]). Soluble fiber was found to be significantly inversely associated with risk of breast cancer (pooled RR, 0.90 [95% CI, 0.84‐0.96; I2 = 12.6%]) and insoluble fiber was found to be suggestively inversely associated with risk of breast cancer (pooled RR, 0.93 [95% CI, 0.86‐1.00; I2 = 33.4%]). Higher total fiber intake was associated with a lower risk of both premenopausal and postmenopausal breast cancers (pooled RR, 0.82 [95% CI, 0.67‐0.99; I2 = 35.2%] and pooled RR, 0.91 [95% CI, 0.88‐0.95; I2 = 0.0%], respectively). Furthermore, the authors observed a nonsignificant inverse association between intake of total fiber and risk of both estrogen and progesterone receptor–positive and estrogen and progesterone receptor–negative breast cancers.
Conclusions: A random‐effects meta‐analysis of prospective observational studies demonstrated that high total fiber consumption was associated with a reduced risk of breast cancer. This finding was consistent for soluble fiber as well as for women with premenopausal and postmenopausal breast cancer.

First Authors:
Maryam S Farvid

Correspondence Authors:
Maryam S Farvid

All Authors:
Maryam S Farvid,Nicholas D Spence,Michelle D Holmes,Junaidah B Barnett

图片
ScienceDaily新闻网站

Fiber consumption linked to lower breast cancer risk

2020-04-06

评论