王刚+谢鹏+胡少华等:或能区分单相和双相抑郁症的肠道菌群标志物
  • 纳入165名重度抑郁(MDD)患者、217名双相障碍(BD)患者和217名健康对照(HC),16S rRNA基因测序分析表明,肠道菌群组成在3组间差异显著;
  • 相比HC组,MDD中13个OTU丰度改变,以拟杆菌科OTU的共变变化为特征,而BD中44个OTU丰度改变,以普雷沃氏菌科、毛螺菌科、瘤胃球菌科OTU的共变变化为特征;
  • 用含26个OTU的菌群标志物,可较准确地区分MDD、BD和HC,其中4个OTU与MDD或BD的严重程度相关。
主编推荐语
mildbreeze
对于重度抑郁症(MDD)和双相情感障碍(BD)患者来说,准确的诊断是正确治疗的前提,但由于两种疾病存在重叠的症状,临床上往往容易出现误诊,从而耽误治疗。首都医科大学北京安定医院王刚团队、重庆医科大学第一附属医院谢鹏团队和浙江大学医学院第一附属医院胡少华团队等合作,近日在Advanced Science发表研究,通过分析对比MDD、BD和健康人的肠道菌群组成,鉴定出可用于区分MDD和BD的菌群特征标志物,为这两种疾病的临床诊断提供新途径。
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Advanced Science [IF:15.84]

Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression

肠道菌群特征可区分单相抑郁症和双相抑郁症

10.1002/advs.201902862

02-05, Article

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Discriminating depressive episodes of bipolar disorder (BD) from major depressive disorder (MDD) is a major clinical challenge. Recently, gut microbiome alterations are implicated in these two mood disorders; however, little is known about the shared and distinct microbial characteristics in MDD versus BD. Here, using 16S ribosomal RNA (rRNA) gene sequencing, the microbial compositions of 165 subjects with MDD are compared with 217 BD, and 217 healthy controls (HCs). It is found that the microbial compositions are different between the three groups. Compared to HCs, MDD is characterized by altered covarying operational taxonomic units (OTUs) assigned to the Bacteroidaceae family, and BD shows disturbed covarying OTUs belonging to Lachnospiraceae, Prevotellaceae, and Ruminococcaceae families. Furthermore, a signature of 26 OTUs is identified that can distinguish patients with MDD from those with BD or HCs, with area under the curve (AUC) values ranging from 0.961 to 0.986 in discovery sets, and 0.702 to 0.741 in validation sets. Moreover, 4 of 26 microbial markers correlate with disease severity in MDD or BD. Together, distinct gut microbial compositions are identified in MDD compared to BD and HCs, and a novel marker panel is provided for distinguishing MDD from BD based on gut microbiome signatures.

First Authors:
Peng Zheng

Correspondence Authors:
Shaohua Hu,Peng Xie,Gang Wang

All Authors:
Peng Zheng,Jian Yang,Yifan Li,Jing Wu,Weiwei Liang,Bangmin Yin,Xunmin Tan,Yu Huang,Tingjia Chai,Hanping Zhang,Jiajia Duan,Jingjing Zhou,Zuoli Sun,Xu Chen,Subhi Marwari,Jianbo Lai,Tingting Huang,Yanli Du,Peifen Zhang,Seth W Perry,Ma-Li Wong,Julio Licinio,Shaohua Hu,Peng Xie,Gang Wang

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