杨恒文+尹芝南:摄入绿茶可预防小鼠的食源性肥胖
创作:szx 审核:szx 2019年11月14日
  • 小鼠分别摄入绿茶或水+标准饮食,持续干预5周后喂食高脂饮食;
  • 预防性摄入绿茶可显著抑制高脂饮食诱导的体重增加,缓解胰岛素抵抗,减少肝脏及脂肪组织中的脂质累积;
  • 小鼠在摄入高脂饮食后,分别摄入绿茶或水+标准饮食,持续5周后继续喂食高脂饮食;
  • 在已经发生食源性肥胖的小鼠中,绿茶无法抑制高脂饮食诱导的体重增加;
  • 预防性摄入绿茶对食源性肥胖的抑制作用在绿茶摄入停止后仍可持续,绿茶的作用可能与其对肠道菌群的调节相关。
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来自暨南大学生物医学转化研究院的杨恒文和尹芝南与团队合作的最新研究,近日在Journal of Functional Foods上发表。该研究发现在小鼠进行高脂饮食之前摄入绿茶,可有效预防高脂饮食诱导的体重增加;而在小鼠的食源性肥胖已经发生后再摄入绿茶,则无此预防效果。绿茶对食源性肥胖有长期预防作用,可能与其对肠道菌群的调节相关。
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Preventive consumption of green tea modifies the gut microbiota and provides persistent protection from high-fat diet-induced obesity

摄入绿茶改变小鼠肠道菌群并持久抑制食源性肥胖

10.1016/j.jff.2019.103621

2019-10-31, Article

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Green tea could reportedly modify gut microbiota and benefit on High-Fat-Diet (HFD) induced obesity. However, most of the studies usually gave green tea (GT) to animals while feeding them HFD. When thin or obese mice, drink GT continuously or only for a period of time, what kind of benefit will them get, is still need to evaluate. In this study, we found that preventive GT consumption by lean mice could prevent HFD-induced-obesity event after stop drinking GT, while the mice with pre-existing obesity couldn’t get such benefit. Gut microbiota structure analysis indicated that the anti-obesity effect by GT consumption always accompanied with microbiota structure modification. We hypothesized that this difference depended upon the status of gut microbiota. Therefore, to gain the persistently protective effect from GT, the precondition is drinking GT before getting fat; otherwise, GT could only slowdown the weight gain of the pre-obese mice by continuously consumption.

First Authors:
Jing Zhu,Ruitian Cai,Yuxiang Tan

Correspondence Authors:
Zhinan Yin,Hengwen Yang

All Authors:
Jing Zhu,Ruitian Cai,Yuxiang Tan,Xiuqing Wu,Qiong Wen,Zonghua Liu,Shu-Hua Ouyang,Zhinan Yin,Hengwen Yang

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