合生制剂可改善特定ADHD患者的部分症状
创作:szx 审核:szx 2020年06月26日
  • 182名ADHD儿童及成年患者随机分为2组,分别补充合生制剂及安慰剂,干预9周;
  • 合生制剂中包含:戊糖片球菌5–33:3/16:1、干酪乳杆菌副干酪亚种F19、植物乳杆菌2362、β-葡聚糖、菊粉、果胶及抗性淀粉;
  • 在改善ADHD症状方面,合生制剂和安慰剂无显著差异;
  • 在干预前sVCAM-1高表达的儿童患者中,合生制剂可缓解自闭症症状及限制性重复刻板行为;
  • 在干预前sVCAM-1高表达的成年患者中,合生制剂可改善情绪调控。
主编推荐语
szx
益生菌、益生元及合生制剂被认为可改善儿童的自闭症症状,但缺乏相关的RCT研究。《Brain Behavior and Immunity》上发表的一项RCT研究,对近200名注意力缺陷多动障碍(ADHD)患者进行为期9周的干预,发现合生制剂Synbiotic 2000(来自瑞典的Synbiotics公司)相比于安慰剂,无法更好地改善患者的ADHD及自闭症症状。但亚组分析显示,在sVCAM-1(在炎症应答中发挥促进作用)高表达的患者中,合生制剂2000可显著改善儿童的自闭症症状,并显著改善成年人情绪调节能力。
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Effects of a synbiotic on symptoms, and daily functioning in attention deficit hyperactivity disorder – A double-blind randomized controlled trial

合生制剂对注意力缺陷多动障碍症状的影响:一项随机双盲安慰剂对照试验

10.1016/j.bbi.2020.05.056

2020-06-01, Article

Abstract & Authors:展开

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Some prebiotics and probiotics have been proposed to improve psychiatric symptoms in children with autism. However, few studies were placebo-controlled, and there is no study on persons with an attention deficit hyperactivity disorder (ADHD) diagnosis. Our aim was to study effects of Synbiotic 2000 on psychiatric symptoms and functioning in children and adults with ADHD without an autism diagnosis. Children and adults (n = 182) with an ADHD diagnosis completed the nine weeks randomized double-blind parallel placebo-controlled trial examining effects of Synbiotic 2000 on the primary endpoints ADHD symptoms, autism symptoms and daily functioning, and the secondary endpoint emotion regulation, measured using the questionnaires SNAP-IV, ASRS, WFIRS, SCQ, AQ and DERS-16. Levels at baseline of plasma C-reactive protein and soluble vascular cell adhesion molecule-1 (sVCAM-1), central to leukocyte-endothelial cell adhesion facilitating inflammatory responses in tissues, were measured using Meso Scale Discovery. Synbiotic 2000 and placebo improved ADHD symptoms equally well, and neither active treatment nor placebo had any statistically significant effect on functioning or sub-diagnostic autism symptoms. However, Synbiotic 2000, specifically, reduced sub-diagnostic autism symptoms in the domain restricted, repetitive and stereotyped behaviors in children, and improved emotion regulation in the domain of goal-directed behavior in adults. In children with elevated sVCAM-1 levels at baseline as well as in children without ADHD medication, Synbiotic 2000 reduced both the total score of autism symptoms, and the restricted, repetitive and stereotyped behaviors. In adults with elevated sVCAM-1 at baseline, Synbiotic 2000 significantly improved emotion regulation, both the total score and four of the five subdomains. To conclude, while no definite Synbiotic 2000-specific effect was detected, the analysis of those with elevated plasma sVCAM-1 levels proposed a reduction of autism symptoms in children and an improvement of emotion regulation in adults with ADHD.

First Authors:
Elin Skott,Liu L Yang

Correspondence Authors:
Catharina Lavebratt

All Authors:
Elin Skott,Liu L Yang,Miranda Stiernborg,Åsa Söderström,Joëlle Rȕegg,Martin Schalling,Yvonne Forsell,MaiBritt Giacobini,Catharina Lavebratt

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