创作:szx 审核:szx 2019年09月06日
  • 纳入451743名欧洲受试者的数据,分析摄入软饮料、含糖软饮料及含人工甜味剂的软饮料与死亡率之间的关联;
  • 在平均16.4年的随访期间,41693名受试者死亡;
  • 每天摄入2杯以上的软饮料、含糖软饮料或含人工甜味剂的软饮料,与更高的全因死亡率相关;
  • 摄入含人工甜味剂的软饮料与循环系统疾病的死亡率呈显著正相关;
  • 摄入含糖软饮料与消化系统疾病的死亡率呈显著正相关。
JAMA Internal Medicine上发表的一项最新队列研究结果,对欧洲的近50万人进行近20年随访后发现,更高的软饮料摄入量与更高的全因死亡率显著相关,含糖软饮料及含人工甜味剂的软饮料也与特定疾病的死亡率相关。

Association Between Soft Drink Consumption and Mortality in 10 European Countries



2019-09-03, Article

Abstract & Authors:展开

Importance : Soft drinks are frequently consumed, but whether this consumption is associated with mortality risk is unknown and has been understudied in European populations to date.
Objective : To examine the association between total, sugar-sweetened, and artificially sweetened soft drink consumption and subsequent total and cause-specific mortality.
Design, Setting, and Participants : This population-based cohort study involved participants (n = 451 743 of the full cohort) in the European Prospective Investigation into Cancer and Nutrition (EPIC), an ongoing, large multinational cohort of people from 10 European countries (Denmark, France, Germany, Greece, Italy, the Netherlands, Norway, Spain, Sweden, and the United Kingdom), with participants recruited between January 1, 1992, and December 31, 2000. Excluded participants were those who reported cancer, heart disease, stroke, or diabetes at baseline; those with implausible dietary intake data; and those with missing soft drink consumption or follow-up information. Data analyses were performed from February 1, 2018, to October 1, 2018.
Exposure : Consumption of total, sugar-sweetened, and artificially sweetened soft drinks.
Main Outcomes and Measures : Total mortality and cause-specific mortality. Hazard ratios (HRs) and 95% CIs were estimated using multivariable Cox proportional hazards regression models adjusted for other mortality risk factors.
Results : In total, 521 330 individuals were enrolled. Of this total, 451 743 (86.7%) were included in the study, with a mean (SD) age of 50.8 (9.8) years and with 321 081 women (71.1%). During a mean (range) follow-up of 16.4 (11.1 in Greece to 19.2 in France) years, 41 693 deaths occurred. Higher all-cause mortality was found among participants who consumed 2 or more glasses per day (vs consumers of <1 glass per month) of total soft drinks (hazard ratio [HR], 1.17; 95% CI, 1.11-1.22; P < .001), sugar-sweetened soft drinks (HR, 1.08; 95% CI, 1.01-1.16; P = .004), and artificially sweetened soft drinks (HR, 1.26; 95% CI, 1.16-1.35; P < .001). Positive associations were also observed between artificially sweetened soft drinks and deaths from circulatory diseases (≥2 glasses per day vs <1 glass per month; HR, 1.52; 95% CI, 1.30-1.78; P < .001) and between sugar-sweetened soft drinks and deaths from digestive diseases (≥1 glass per day vs <1 glass per month; HR, 1.59; 95% CI, 1.24-2.05; P < .001).
Conclusions and Relevance : This study found that consumption of total, sugar-sweetened, and artificially sweetened soft drinks was positively associated with all-cause deaths in this large European cohort; the results are supportive of public health campaigns aimed at limiting the consumption of soft drinks.

First Authors:
Amy Mullee,Dora Romaguera

Correspondence Authors:
Neil Murphy

All Authors:
Amy Mullee,Dora Romaguera,Jonathan Pearson-Stuttard,Vivian Viallon,Magdalena Stepien,Heinz Freisling,Guy Fagherazzi,Francesca Romana Mancini,Marie-Christine Boutron-Ruault,Tilman Kühn,Rudolf Kaaks,Heiner Boeing,Krasimira Aleksandrova,Anne Tjønneland,Jytte Halkjær,Kim Overvad,Elisabete Weiderpass,Guri Skeie,Christine L Parr,J Ramón Quirós,Antonio Agudo,María José Sanchez,Pilar Amiano,Lluís Cirera,Eva Ardanaz,Kay-Tee Khaw,Tammy Y N Tong,Julie A Schmidt,Antonia Trichopoulou,Georgia Martimianaki,Anna Karakatsani,Domenico Palli,Claudia Agnoli,Rosario Tumino,Carlotta Sacerdote,Salvatore Panico,Bas Bueno-de-Mesquita,W M Monique Verschuren,Jolanda M A Boer,Roel Vermeulen,Stina Ramne,Emily Sonestedt,Bethany Van Guelpen,Pernilla Lif Holgersson,Konstantinos K Tsilidis,Alicia K Heath,David Muller,Elio Riboli,Marc J Gunter,Neil Murphy

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