合生制剂或可用于预防呼吸道感染
创作:王文东 审核:szx 2020年02月21日
  • 纳入16项符合条件的RCT(涉及10443名受试者)进行荟萃分析,评估补充合生制剂对预防呼吸道感染(RTI)的临床效果;
  • 补充合生制剂使RTI发病率降低16%,并使正在经历RTI的受试者降低16%,未发现显著的发表偏倚;
  • 亚组分析显示,相比婴儿和儿童,补充合生制剂预防成年人RTI的效果更加显著;
  • 排除将益生菌或益生元作为对照组的RCT进行敏感性分析(将安慰剂作为对照组),所得结果与上述结论一致。
主编推荐语
szx
Advances in Nutrition上发表的一项荟萃分析结果,对16项RCT(涉及超过1万名受试者)进行总结后发现,补充合生制剂可显著降低呼吸道感染的发病率,且相比于婴儿及儿童,合生制剂在成年人中预防呼吸道感染的效果更好。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

Preventing Respiratory Tract Infections by Synbiotic Interventions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

补充合生制剂预防呼吸道感染:一项随机对照试验的系统性回顾和荟萃分析

10.1093/advances/nmaa003

2020-01-29, Article

Abstract & Authors:展开

Abstract:收起
Dysbiosis of the human gut microbiome has been linked to various health conditions, including respiratory tract infections (RTIs) through the gut–lung axis. Several trials have reported that synbiotic therapy could help prevent RTIs or relieve symptoms of some diseases. This meta-analysis comprehensively evaluates the clinical effects of synbiotic supplements for preventing RTIs. PubMed and Google Scholar were searched by keywords for eligible clinical trials until April 2019. Sixty-two studies were retrieved, and 16 studies were selected for meta-analysis. The primary outcomes were defined as the proportion of participants with RTIs at least once or the times of RTI episodes during follow-up based on the intention-to-treat approach. Overall, synbiotic interventions reduced the incidence rate of RTIs by 16% (95% CI: 4%, 27%) and the proportion of participants experiencing RTIs by 16% (95% CI: 5%, 26%). There was no significant evidence of publication bias. A subgroup analysis suggested more prominent effects of synbiotics among adults than infants and children for RTI prevention. The sensitivity analysis excluding trials with prebiotics or probiotics as controls was consistent with our primary analysis. This meta-analysis of clinical trials involving >10,000 individuals showed that synbiotic interventions could be an alternative nutrition strategy for conferring human health and preventing RTIs. Future investigations on the clinical efficacy and safety of synbiotic interventions are warranted with strain-specific and dose-specific approaches.

First Authors:
Carty K Y Chan,Jun Tao

Correspondence Authors:
Herbert Pang

All Authors:
Carty K Y Chan,Jun Tao,Olivia S Chan,Hua-Bin Li,Herbert Pang

评论