国内团队Cell突破:在单细胞层面系统性揭示节食如何延缓衰老
创作:mildbreeze 审核:mildbreeze 03月01日
  • 用单细胞转录组学和单核转录组学方法,分析衰老和热量限制(CR)对大鼠不同器官组织的影响;
  • 衰老使细胞类型组成、细胞和组织特异性基因表达、转录调控和细胞间通讯等都发生改变,CR可减轻这些变化;
  • 嗜中性粒细胞等免疫细胞随衰老增加,可被CR可逆转;
  • 超过1/4的衰老相关基因表达变化(包括一些与脂代谢和免疫调节相关的核心调控转录因子)可被CR逆转;
  • 衰老还伴随着细胞间通讯模式异常,包括过度的促炎配体-受体互作等,可被CR逆转。
主编推荐语
mildbreeze
热量限制可延缓衰老相关的身体机能衰退。Cell最新发表了来自中国科学院动物研究所刘光慧和曲静团队以及中国科学院基因组研究所张维绮团队共同参与主导的研究,在单细胞层面揭示了热量限制对衰老的系统性影响,表明对衰老相关炎症反应的抑制作用,是热量限制延缓衰老的重要因素,提示饮食和代谢干预可从整体上影响机体的免疫状态,对于研究健康衰老和改善老年健康的干预手段有重要参考价值。
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Cell [IF:38.637]

Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging

热量限制重编大鼠衰老的单细胞转录图谱

10.1016/j.cell.2020.02.008

02-27, Article

Abstract & Authors:展开

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Aging causes a functional decline in tissues throughout the body that may be delayed by caloric restriction (CR). However, the cellular profiles and signatures of aging, as well as those ameliorated by CR, remain unclear. Here, we built comprehensive single-cell and single-nucleus transcriptomic atlases across various rat tissues undergoing aging and CR. CR attenuated aging-related changes in cell type composition, gene expression, and core transcriptional regulatory networks. Immune cells were increased during aging, and CR favorably reversed the aging-disturbed immune ecosystem. Computational prediction revealed that the abnormal cell-cell communication patterns observed during aging, including the excessive proinflammatory ligand-receptor interplay, were reversed by CR. Our work provides multi-tissue single-cell transcriptional landscapes associated with aging and CR in a mammal, enhances our understanding of the robustness of CR as a geroprotective intervention, and uncovers how metabolic intervention can act upon the immune system to modify the process of aging.

First Authors:
Shuai Ma,Shuhui Sun,Lingling Geng,Moshi Song

Correspondence Authors:
Juan Carlos Izpisua Belmonte,Weiqi Zhang,Jing Qu,Guang-Hui Liu

All Authors:
Shuai Ma,Shuhui Sun,Lingling Geng,Moshi Song,Wei Wang,Yanxia Ye,Qianzhao Ji,Zhiran Zou,Si Wang,Xiaojuan He,Wei Li,Concepcion Rodriguez Esteban,Xiao Long,Guoji Guo,Piu Chan,Qi Zhou,Juan Carlos Izpisua Belmonte,Weiqi Zhang,Jing Qu,Guang-Hui Liu

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Science Translational Medicine期刊

“You are what you eat!”

2020-03-11

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中国生物技术网微信公众号

少即是“多”!Cell揭示:何以健康,唯有少食...

2020-02-28

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