Nature子刊:婴儿期吃太多,恐不利于肠道健康
  • 用3种方法让新生小鼠摄入过多热量,均会增加断奶时的肠道通透性、促炎细胞因子和菌群产生的有毒硫化氢;
  • 这些肠道变化彼此之间互相促进,导致成年后的结肠炎易感性明显上升;
  • 对这些小鼠在断奶期间采用一些预防措施(用抗体中和IFN-γ和TNF-α、用美沙拉嗪阻断细菌生成硫化氢、用药物抑制肌球蛋白轻链激酶来改善肠道通透性),则可降低结肠炎风险;
  • 生命早期摄入过多热量,可对肠道健康造成多种影响,增加炎症性肠病的长期风险。
主编推荐语
mildbreeze
肥胖与炎症性肠病(IBD)存在密切关联,在动物研究中,孕期的高脂喂养和肥胖,可增加后代患IBD的风险。Nature Metabolism发表的一项最新研究表明,在断奶前的新生儿和婴儿期吃得过多,不利于小鼠的肠道健康,可增加成年后患IBD的风险。这些发现提示,出生后至断奶前是塑造肠道长期健康的关键时期。
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Excess calorie intake early in life increases susceptibility to colitis in adulthood

生命早期的过多热量摄入,增加成年期的结肠炎易感性

10.1038/s42255-019-0129-5

2019-11-04, Article

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Epidemiological data reveal an association between obesity and inflammatory bowel disease (IBD). Furthermore, animal models demonstrate that maternal high-fat diet (HFD) and maternal obesity increase susceptibility to IBD in offspring. Here we report that excess calorie intake by neonatal mice, as a consequence of maternal HFD, forced feeding of neonates or low litter competition, leads to an increase during weaning in intestinal permeability, expression of pro-inflammatory cytokines and hydrogen sulfide production by the microbiota. These intestinal changes engage in mutual positive feedback that imprints increased susceptibility to colitis in adults. The pathological imprinting is prevented by the neutralization of IFN-γ and TNF-α or the production of hydrogen sulfide, or by normalization of intestinal permeability during weaning. We propose that excess calorie intake by neonates leads to multiple causally linked perturbations in the intestine that imprint the individual with long-term susceptibility to IBD.

First Authors:
Ziad Al Nabhani

Correspondence Authors:
Ziad Al Nabhani,Gerard Eberl

All Authors:
Ziad Al Nabhani,Sophie Dulauroy,Emelyne Lécuyer,Bernadette Polomack,Pascal Campagne,Marion Berard,Gerard Eberl

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Science Translational Medicine期刊

Colitis from a chubby colon

Ming Yang,2019-12-04

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