Science子刊:口腔菌群-宿主互作中的Th17型免疫(综述)
创作:szx 审核:szx 02月04日
  • 口腔菌群与结肠癌、阿尔兹海默症等系统性疾病相关,牙周炎与心血管疾病、糖尿病等系统性疾病相关;
  • Th17细胞介导的免疫应答在牙周免疫及炎症中发挥重要作用;
  • 健康状态下,局部组织损伤触发上皮细胞分泌IL-6,以抗原依赖性方式诱导Th17细胞的累积,Th17细胞分泌IL-17以介导保护性屏障应答;
  • 牙周炎中,口腔菌群失调引发牙龈中的Th17细胞扩增,触发IL-6及IL-23依赖性Th17细胞累积,Th17细胞通过招募过量的中性粒细胞驱动牙周骨丢失。
主编推荐语
szx
口腔粘膜通常是悬浮颗粒、菌群及食物进入胃肠道或呼吸道的第一道屏障。Science Immunology上发表的一篇综述文章,详细介绍了在口腔健康及口腔疾病状态下,口腔粘膜处Th17细胞介导的免疫应答,包括Th17型免疫应答在维持屏障完整性及抑制病原体感染中,以及异常的Th17型免疫应答在驱动牙周炎等口腔疾病中的作用机制。
关键字
延伸阅读本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!
图片
Science Immunology [IF:13.44]

Regulation of host-microbe interactions at oral mucosal barriers by type 17 immunity

Th17型免疫在口腔粘膜屏障处对宿主-菌群互作的调节

10.1126/sciimmunol.aau4594

01-03, Review

Abstract & Authors:展开

Abstract:收起
The oral mucosa is a primary barrier site and a portal for entry of microbes, food, and airborne particles into the gastrointestinal tract. Nonetheless, mucosal immunity at this barrier remains understudied compared with other anatomical barrier sites. Here, we review basic aspects of oral mucosal histology, the oral microbiome, and common and clinically significant diseases that present at oral mucosal barriers. We particularly focus on the role of interleukin-17 (IL-17)/T helper 17 (TH17) responses in protective immunity and inflammation in the oral mucosa. IL-17/TH17 responses are highly relevant to maintaining barrier integrity and preventing pathogenic infections by the oral commensal fungus Candida albicans. On the other hand, aberrant IL-17/TH17 responses are implicated in driving the pathogenesis of periodontitis and consequent bone and tooth loss. We discuss distinct IL-17–secreting T cell subsets, emphasizing their regulation and function in oropharyngeal candidiasis and periodontitis.

First Authors:
Sarah L Gaffen,Niki M Moutsopoulos

Correspondence Authors:
Sarah L Gaffen,Niki M Moutsopoulos

All Authors:
Sarah L Gaffen,Niki M Moutsopoulos

评论