西南大学:合生制剂在小鼠中的降脂作用
创作:楸楸 审核:兵兵 2020年07月10日
  • 植物乳杆菌S58 (LP.S58)与去壳大麦β-葡聚糖(β-G)协同干预下,高脂膳食小鼠体重、血脂、脂肪和肝脏组织纸质积累均降低;
  • LP.S58与β-G协同激活AMPK信号通路,加速脂解、脂肪酸氧化,抑制脂肪酸摄取和脂质合成来减少脂质积累;
  • LP.S58与β-G协同增加结肠紧密连接蛋白的表达,修复结粘膜屏障,并抑制炎症;
  • 同时,两者协同可以改善肠道菌群,促进脂质代谢相关激素的分泌;
  • LP.S58和β-G可用作功能性食品成分,防止肥胖症中脂质的积聚。
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兵兵
西南大学索化夷团队研究成果。文章用植物乳杆菌S58 (LP.S58)与去壳大麦β-葡聚糖(β-G)共同干预高脂膳食小鼠。研究结果显示,在LP.S58与β-G的协同干预下,高脂膳食小鼠的体重、体脂均降低,进一步研究表明这种效果是通过激活AMPK通路实现的。并且,两者的干预还可以调节肠道菌群,保护肠道屏障的完整性等。该研究初步表明,LP.S58与β-G通过调节肠道菌群以及激活AMPK通路的方式降低高脂膳食小鼠的脂质积累。两者组成的合生元或可作为减肥功能食品。
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A synbiotic consisting of Lactobacillus plantarum S58 and hull-less barley β-glucan ameliorates lipid accumulation in mice fed with a high-fat diet by activating AMPK 

由植物乳杆菌S58和无壳大麦β-葡聚糖组成的合生元通过激活AMPK信号传导和调节肠道菌群改善高脂饮食喂养小鼠的脂质蓄积

10.1016/j.carbpol.2020.116398

2020-05-24, Article

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The synergistic effects of Lactobacillus plantarum S58 (LP.S58) and hull-less barley β-glucan (β-G) on lipid accumulation in mice fed with a high-fat diet (HFD) were Journal Pre-proof investigated. The body weight, serum lipid levels and lipid accumulation of adipose and liver tissues in the HFD-fed mice were inhibited after synergistic treatment with LP.S58 and β-G. In liver and adipose tissues, LP.S58 and β-G synergistically activated AMPK, reduced the expression of PPARγ, C/EBPα, SREBP-1c, FAS, SCD1 and LPL, and increased the expression of CPT-1 and HSL. The HFD-induced decreases in lipid metabolism-related hormones were reversed by LP.S58 and β-G. LP.S58 and β-G synergistically also increased the expression of colon tight junction proteins while suppressing systematic inflammation. LP.S58 and β-G ameliorated gut microbiological dysbiosis in HFD-fed mice. Correlations between serum parameters and gut microbiota were revealed. LP.S58 and β-G synergistically attenuated the HFD-induced lipid accumulation by activating AMPK signaling and regulating the gut microbiota.

First Authors:
Tian Tang,Jiajia Song

Correspondence Authors:
Huayi Suo

All Authors:
Tian Tang,Jiajia Song,Jian Li,Hongwei Wang,Yu Zhang,Huayi Suo

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