早期菌群与儿童生长(综述)
创作:無李 审核:mildbreeze 2018年11月03日
  • 母体肠道和阴道菌群可作用于子宫内环境,影响怀孕和胎儿生长;
  • 母乳富含人乳寡糖,对婴儿早期肠道菌群发育有关键作用;
  • 6月龄至2岁,肠道菌群趋于成熟,受营养和环境的影响,Akk菌、柔嫩梭菌和专性厌氧菌等促进生长健康,而大肠杆菌、金黄色葡萄球菌等与营养不良有关;
  • 肠道菌群调节IGF-1和生长激素生成、影响炎症和肠病,从而影响生长;
  • 通过饮食、抗生素、益生菌/元或粪菌移植等干预措施,调节生命早期菌群,可促进健康生长发育。
主编推荐语
mildbreeze
从怀孕开始至出生后2岁的1000天,是生命早期菌群形成和影响生长发育的关键时期。Trends in Microbiology近期发表综述对此进行详细探讨,值得专业人士关注。
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The Human Microbiome and Child Growth – First 1000 Days and Beyond

人体微生物组和儿童生长——第一个1000天及以后

10.1016/j.tim.2018.09.008

2018-10-24, Review

Abstract & Authors:展开

Abstract:收起
The assembly of microbial communities within the gastrointestinal tract during early life plays a critical role in immune, endocrine, metabolic, and other host developmental pathways. Environmental insults during this period, such as food insecurity and infections, can disrupt this optimal microbial succession, which may contribute to lifelong and intergenerational deficits in growth and development. Here, we review the human microbiome in the first 1000 days – referring to the period from conception to 2 years of age – and using a developmental model, we examine the role of early microbial succession in growth and development. We propose that an ‘undernourished’ microbiome is intergenerational, thereby perpetuating growth impairments into successive generations. We also identify and discuss the intertwining host–microbe–environment interactions occurring prenatally and during early infancy, which may impair the trajectories of healthy growth and development, and explore their potential as novel microbial targets for intervention.

First Authors:
Ruairi C Robertson

Correspondence Authors:
Ruairi C Robertson

All Authors:
Ruairi C Robertson,Amee R Manges,B Brett Finlay,Andrew J Prendergast

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