一文读懂新假说:母亲饮食结构如何影响婴儿肠道菌群?(综述)
创作:尹小甜 审核:Epi汪 03月05日
  • 一些研究已发现母乳和婴儿肠道样本之间存在共有的微生物,包括双歧杆菌和噬菌体,提示母乳菌群可能影响婴儿肠道菌群;
  • 而母乳中菌群可能通过“肠道-乳腺”获得,即来源于母亲的肠道菌群;
  • 另外有限的证据表明,孕妇可以通过孕期饮食调节肠道菌群;
  • 基于此,存在一种可信的假说:哺乳期母亲的饮食结构可能通过影响自身肠道菌群,从而影响乳汁菌群,进而影响婴儿的肠道菌群结构。
主编推荐语
Epi汪
本综述通过现有文献证据阐明了母亲饮食结构、母亲肠道菌群、母乳菌群及婴儿肠道菌群四个物质之间潜在的关联。由于婴儿肠道菌群结构可能对长远的健康产生影响,所以如果该假说成立,通过干预母亲饮食结构调整婴儿肠道菌群结构,势在必行。
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Can we modulate the breastfed infant gut microbiota through maternal diet?

我们可以通过改变母亲饮食来调节母乳喂养的婴儿肠道菌群吗?

10.1093/femsre/fuab011

02-11, Review

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Initial colonisation of the infant gut is robustly influenced by regular ingestion of human milk, a substance that contains microbes, microbial metabolites, immune proteins, and oligosaccharides. Numerous factors have been identified as potential determinants of the human milk and infant gut microbiota, including maternal diet; however, there is limited data on the influence of maternal diet during lactation on either of these. Here, we review the processes thought to contribute to human milk and infant gut bacterial colonisation and provide a basis for considering the role of maternal dietary patterns during lactation in shaping infant gut microbial composition and function. Although only one observational study has directly investigated the influence of maternal diet during lactation on the infant gut microbiome, data from animal studies suggests that modulation of the maternal gut microbiota, via diet or probiotics, may influence the mammary or milk microbiota. Additionally, evidence from human studies suggests that the maternal diet during pregnancy may affect the gut microbiota of the breastfed infant. Together, there is a plausible hypothesis that maternal diet during lactation may influence the infant gut microbiota. If substantiated in further studies, this may present a potential window of opportunity for modulating the infant gut microbiome in early life.

First Authors:
Azhar S Sindi

Correspondence Authors:
Lisa F Stinson

All Authors:
Azhar S Sindi,Donna T Geddes,Mary E Wlodek,Beverly S Muhlhausler,Matthew S,Payne,Lisa F Stinson

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