Science:肠道菌群周期性调节身体成分的一种机制
创作:szx 审核:szx 2017年10月01日
  • NFIL3是一种在免疫细胞及小肠上皮细胞中表达的转录因子,无菌小鼠的NFIL3表达显著减少;
  • 肠道上皮细胞中的Nfil3基因的转录水平表现出节律性振荡,其振幅受到肠道菌群调控;
  • 肠道菌群通过3型天然淋巴细胞、STAT3及肠道上皮细胞生物钟对NFIL3起到调控作用;
  • NFIL3控制节律性脂质代谢程序的表达,并调节肠道上皮细胞的脂质吸收及运出,从而调节身体成分。
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蓝灿辉 | 热心肠先生
这是Science上周发出的一项重要研究,揭示NFIL3这一转录因子如何受肠道菌群调节,从而周期性调节脂质代谢和身体成分。很值得专业人士关注,特别推荐。
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Science [IF:41.845]

The intestinal microbiota regulates body composition through NFIL3 and the circadian clock

肠道菌群通过NFIL3及生物钟调节身体成分

10.1126/science.aan0677

2017-09-01, Article

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The intestinal microbiota has been identified as an environmental factor that markedly affects energy storage and body-fat accumulation in mammals, yet the underlying mechanisms remain unclear. Here we show that the microbiota regulates body composition through the circadian transcription factor NFIL3. Nfil3 transcription oscillates diurnally in intestinal epithelial cells, and the amplitude of the circadian oscillation is controlled by the microbiota through group 3 innate lymphoid cells, STAT3 (signal transducer and activator of transcription 3), and the epithelial cell circadian clock. NFIL3 controls expression of a circadian lipid metabolic program and regulates lipid absorption and export in intestinal epithelial cells. These findings provide mechanistic insight into how the intestinal microbiota regulates body composition and establish NFIL3 as an essential molecular link among the microbiota, the circadian clock, and host metabolism.

First Authors:
Yuhao Wang

Correspondence Authors:
Lora V Hooper

All Authors:
Yuhao Wang,Zheng Kuang,Xiaofei Yu,Kelly A Ruhn,Masato Kubo,Lora V Hooper

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