帕金森病患者的肠道菌群变化
创作:szx 审核:szx 03月17日
  • 纳入10项病例-对照研究(涉及9个队列中的1269份样本)进行荟萃分析,总结帕金森病患者的肠道菌群变化;
  • 相比于对照,帕金森病患者的肠道菌群表现出微小但显著的改变,且不受研究方法异质性的影响;
  • 帕金森病患者的肠道菌群中,乳杆菌属、Akk菌属、双歧杆菌属富集,而毛螺菌科及粪杆菌属等重要的产短链脂肪酸菌减少;
  • 这些变化可能导致促炎症状态,并与帕金森病患者的复发性胃肠道症状相关。
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szx
npj Parkinsons Disease上发表的一项荟萃分析结果,基于10项病例-对照研究的数据,总结了帕金森病患者的肠道菌群变化。
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Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation

荟萃分析结果提示帕金森病患者的肠道菌群变化与肠道炎症相关

10.1038/s41531-021-00156-z

03-10, Article

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The gut microbiota is emerging as an important modulator of neurodegenerative diseases, and accumulating evidence has linked gut microbes to Parkinson’s disease (PD) symptomatology and pathophysiology. PD is often preceded by gastrointestinal symptoms and alterations of the enteric nervous system accompany the disease. Several studies have analyzed the gut microbiome in PD, but a consensus on the features of the PD-specific microbiota is missing. Here, we conduct a meta-analysis re-analyzing the ten currently available 16S microbiome datasets to investigate whether common alterations in the gut microbiota of PD patients exist across cohorts. We found significant alterations in the PD-associated microbiome, which are robust to study-specific technical heterogeneities, although differences in microbiome structure between PD and controls are small. Enrichment of the genera Lactobacillus, Akkermansia, and Bifidobacterium and depletion of bacteria belonging to the Lachnospiraceae family and the Faecalibacterium genus, both important short-chain fatty acids producers, emerged as the most consistent PD gut microbiome alterations. This dysbiosis might result in a pro-inflammatory status which could be linked to the recurrent gastrointestinal symptoms affecting PD patients.

First Authors:
Stefano Romano

Correspondence Authors:
Stefano Romano,Falk Hildebrand

All Authors:
Stefano Romano,George M Savva,Janis R Bedarf,Ian G Charles,Falk Hildebrand,Arjan Narbad

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