一图读懂:人与肠道菌群休戚与共的一生(必读Cell综述)
  • 共生体的概念被认可和传播,人类从根本上改进了对进化、健康、疾病和衰老的认识;
  • 在人体发育的不同阶段,肠道微生物有对应特征并充分影响生理功能;
  • 衰老进程中,运动减少、营养改变、药物和居住状态变化均会影响微生物及其产物,带来生理和免疫变化;
  • 人体自身基因组很难改变,而微生物组却可通过粪菌移植、益生元/菌、抗生素等众多手段干预调节;
  • 微生物组的改变会影响大脑和神经功能,人的精神和意识很大程度上也是属于微生物的。
#一张图读懂系列文献#
主编推荐语
热心肠先生
这是最新一期Cell发表的重量级综述,系统性介绍了人体与微生物组成的“共生体”是如何共栖共生一生的。写文章的人够大牌,干货够多,所以没有人可以错过这么精彩的文章,请好好读一读,实在偷懒,也要至少读一读我们编译的“一图读懂”哦。
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Cell [IF:66.85]

Our Gut Microbiome: The Evolving Inner Self

我们的肠道微生物组:进化中的内在自我

10.1016/j.cell.2017.11.024

2017-12-14, Review

Abstract & Authors:展开

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The "holobiont" concept, defined as the collective contribution of the eukaryotic and prokaryotic counterparts to the multicellular organism, introduces a complex definition of individuality enabling a new comprehensive view of human evolution and personalized characteristics. Here, we provide snapshots of the evolving microbial-host associations and relations during distinct milestones across the lifespan of a human being. We discuss the current knowledge of biological symbiosis between the microbiome and its host and portray the challenges in understanding these interactions and their potential effects on human physiology, including microbiome-nervous system inter-relationship and its relevance to human variation and individuality.

First Authors:
Parag Kundu,Eran Blacher

Correspondence Authors:
Parag Kundu,Eran Elinav,Sven Pettersson

All Authors:
Parag Kundu,Eran Blacher,Eran Elinav,Sven Pettersson

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