Cell:生酮饮食改变肠道菌群,减少肠道Th17
创作:mildbreeze 审核:mildbreeze 06月01日
  • 分析住院病人4周正常饮食+4周生酮饮食(KD)期间的粪便样本,发现KD明显改变了肠道菌群的结构和代谢物,放线菌(及其中的双歧杆菌属)和厚壁菌减少、拟杆菌增多;
  • 在小鼠中,KD和高脂饮食(HFD)对菌群组成有不同影响,KD的独特性主要体现在双歧杆菌的耗竭;
  • 体外和小鼠试验显示,KD诱导产生的酮体部分驱动了菌群的变化,β-羟基丁酸能选择性的抑制双歧杆菌生长;
  • 限菌小鼠试验表明,KD相关肠道菌群能减少促炎的肠道Th17细胞。
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mildbreeze
极低碳水高脂的生酮饮食(KD)是比高脂饮食(HFD)更极端的饮食模式,可用于干预特定疾病。KD可引起酮体生成,从而改变身体的能源类型,但人们并不清楚酮体如何影响宿主-菌群互作。《Cell》最新发表了来自美国加州大学旧金山分校的Peter J. Turnbaugh团队的研究,通过人体干预试验+小鼠模型试验,揭示了KD对肠道菌群的影响和机制,以及相关的免疫调节作用。他们发现,KD与HFD对肠道菌群的改变是有明显差异的。KD的独特性在于,其诱导生成的酮体能选择性的抑制肠道内的双歧杆菌,从而减少肠道固有层中有促炎作用的Th17细胞。这些发现强调了宿主与微生物间的化学对话,在介导饮食干预功效中的重要性。
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Cell [IF:38.637]

Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells

生酮饮食改变肠道微生物组导致肠道Th17细胞减少

10.1016/j.cell.2020.04.027

05-20, Article

Abstract & Authors:展开

Abstract:收起
Very low-carbohydrate, high-fat ketogenic diets (KDs) induce a pronounced shift in metabolic fuel utilization that elevates circulating ketone bodies; however, the consequences of these compounds for host-microbiome interactions remain unknown. Here, we show that KDs alter the human and mouse gut microbiota in a manner distinct from high-fat diets (HFDs). Metagenomic and metabolomic analyses of stool samples from an 8-week inpatient study revealed marked shifts in gut microbial community structure and function during the KD. Gradient diet experiments in mice confirmed the unique impact of KDs relative to HFDs with a reproducible depletion of bifidobacteria. In vitro and in vivo experiments showed that ketone bodies selectively inhibited bifidobacterial growth. Finally, mono-colonizations and human microbiome transplantations into germ-free mice revealed that the KD-associated gut microbiota reduces the levels of intestinal pro-inflammatory Th17 cells. Together, these results highlight the importance of trans-kingdom chemical dialogs for mediating the host response to dietary interventions.

First Authors:
Qi Yan Ang

Correspondence Authors:
Peter J Turnbaugh

All Authors:
Qi Yan Ang,Margaret Alexander,John C Newman,Yuan Tian,Jingwei Cai,Vaibhav Upadhyay,Jessie A Turnbaugh,Eric Verdin,Kevin D Hall,Rudolph L Leibel,Eric Ravussin,Michael Rosenbaum,Andrew D Patterson,Peter J Turnbaugh

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转化医学网微信公众号

【Cell】美国最新研究:生酮饮食影响人体肠道微生物

转网,2020-05-21

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生物通微信公众号

Cell:生酮饮食改变人体的肠道微生物组

生物通小通,2020-05-21

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Medical Xpress新闻网站

Ketogenic diets alter gut microbiome in humans, mice

2020-05-20

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微生态微信公众号

Cell | 生酮饮食改变肠道微生物群导致肠道Th17细胞减少

番茄加牛腩同学,2020-06-08

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Cell Host and Microbe期刊

Going Keto? Say βHB-ye Bye to Your Gut Bifidobacteria

2020-07-08

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